促进铁死亡的脂肪酸代谢使癌细胞具有免疫原性。
Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic.
机构信息
Equipe labellisée par la Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France.
Equipe labellisée par la Ligue contre le cancer, Université de Paris Cité, Sorbonne Université, INSERM UMR1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Institut Universitaire de France, 75005 Paris, France.
出版信息
Trends Cancer. 2022 Oct;8(10):785-787. doi: 10.1016/j.trecan.2022.04.002. Epub 2022 Apr 22.
Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.
肿瘤细胞内在的代谢特征可以影响癌症免疫对话。在最近发表在《癌细胞》杂志上的一篇论文中，Liao 等人表明，T 细胞产生的 IFNγ 与花生四烯酸一起，可以诱导酰基辅酶 A 合成酶长链家族成员 4（ACSL4）介导的铁死亡，与增强免疫监测和对检查点阻断的反应相关。
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