School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi Province 710049, China.
School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an, Shaanxi Province 710055, China.
J Hazard Mater. 2022 Jun 15;432:128539. doi: 10.1016/j.jhazmat.2022.128539. Epub 2022 Mar 4.
The discharge of personal care products (PPCPs) to sewer systems increased due to the rapid expansion of cities, while PPCPs transformation in sewer and the potential threat to receiving water environments have been rarely revealed. In this study, six PPCPs (antibiotics, generic drugs and personal care products) were added continuously over a 90-day experimental period to investigate the effect of transformation in a pilot sewer. The results showed that the biological metabolism of carbon, nitrogen and phosphorus pollutants were restricted under the PPCPs stress condition. The genomic detection also confirmed that the diversity of microflora in sewer sediment were obviously decreased with the PPCPs transformation, and the total relative abundance of dominant phylum species (Firmicutes, Bacteroidetes and Proteobacteria) increased from 67.7% to 94.9%. In addition, principal coordinate analysis and metagenome showed that the two kinds of antibiotics were the most important inducement for the metabolic dysfunction in sewer systems, and led to the increase of functional gene of "Human Disease" (accounted for 0.97%) which could form more harmful metabolites to cause serious exposure hazards. Thus, this investigation provided the insights into the metabolic hazards of PPCPs bioconversions in sewers, which hoped to bring to the forefront of PPCPs emission to sewers by society.
个人护理产品（PPCPs）由于城市的快速扩张而排放到污水系统中的量增加，而 PPCPs 在污水中的转化及其对受纳水环境的潜在威胁却很少被揭示。在这项研究中，连续 90 天的实验中添加了六种 PPCPs（抗生素、非专利药和个人护理产品），以研究中试污水中转化的影响。结果表明，在 PPCPs 胁迫条件下，碳、氮和磷污染物的生物代谢受到限制。基因组检测还证实，随着 PPCPs 的转化，污水沉积物中微生物群落的多样性明显减少，优势门（Firmicutes、Bacteroidetes 和 Proteobacteria）的总相对丰度从 67.7%增加到 94.9%。此外，主坐标分析和宏基因组表明，这两种抗生素是导致污水系统代谢功能障碍的最重要诱因，导致“人类疾病”功能基因（占 0.97%）增加，可能形成更多有害代谢物，造成严重的暴露危害。因此，这项研究深入了解了 PPCPs 在污水中的生物转化的代谢危害，希望引起社会对 PPCPs 排放到污水中的关注。
