COVID-19 患者垂体和肾上腺的死后组织病理学。
Post-mortem histopathology of pituitary and adrenals of COVID-19 patients.
机构信息
Institute of Legal Medicine of the University Medical Center Hamburg-Eppendorf, Germany.
Institutes of Pathology and Neuropathology of the University Medical Center Hamburg-Eppendorf, Germany.
出版信息
Leg Med (Tokyo). 2022 Jul;57:102045. doi: 10.1016/j.legalmed.2022.102045. Epub 2022 Feb 25.
BACKGROUND
Knowledge of the exact organ manifestation is essential for a comprehensive understanding of COVID-19 infection. Here, the histopathological changes in the pituitary and adrenal glands were analyzed.
METHODS
In this series, the formalin-fixed tissues of 63 pituitary glands and 50 adrenal glands were examined. We performed HE and PAS staining and examined COVID-19 nucleocapsid antibody immunohistochemically in the pituitary glands and adrenals.
RESULTS
Histologically, there was no evidence of COVID-19-specific changes in the pituitary and adrenal glands. Large pituitary necrosis may be interpreted as a shock reaction. Independent of infection, we found one T-cell lymphoma, two adenomas, and four Rathke-type cysts in the pituitary glands, and 70% of the adrenal glands showed decreased lipid content and an increase in compact cells as a stress response. In addition, a cortical adenoma in one adrenal gland and small cortical nodules in three adrenal glands were detected independently of COVID-19.
CONCLUSION
Pituitary and adrenal glands do not appear histologically predominant in the course of COVID-19.
背景
了解确切的器官表现对于全面了解 COVID-19 感染至关重要。在此，分析了垂体和肾上腺的组织病理学变化。
方法
在本系列中，检查了 63 个垂体和 50 个肾上腺的福尔马林固定组织。我们对垂体和肾上腺进行了 HE 和 PAS 染色，并进行了 COVID-19 核衣壳抗体免疫组织化学检查。
结果
组织学上，垂体和肾上腺均未发现 COVID-19 特异性变化。大的垂体坏死可能被解释为休克反应。与感染无关，我们在垂体中发现了一个 T 细胞淋巴瘤、两个腺瘤和四个 Rathke 型囊肿，70%的肾上腺显示出脂质含量减少和致密细胞增加作为应激反应。此外，一个肾上腺中的皮质腺瘤和三个肾上腺中的小皮质结节独立于 COVID-19 而被检测到。
结论
在 COVID-19 病程中，垂体和肾上腺在组织学上似乎没有占主导地位。
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