减轻苯二氮䓬类药物依赖和治疗胃轻瘫时药物引起的 QTc 延长风险：病例报告。
Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report.
机构信息
College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA.
MedWiseRx, 100 N Stone Ave., Tucson, AZ 85701, USA.
出版信息
Medicina (Kaunas). 2022 Mar 10;58(3):409. doi: 10.3390/medicina58030409.
Abstract
Patients are often faced with challenges when it comes to safe therapeutic options. An 89-year-old female with a history of arrhythmias and refractory gastroparesis complained of adverse drug events from her benzodiazepine. While performing a comprehensive medication review and a medication safety review using an advanced clinical decision support system, the pharmacist successfully tapered off the benzodiazepine to a safer alternative antidepressant indicated for the treatment of gastroparesis. Special attention was given to selecting drugs with less QT prolongation risk, based on her age, current drug regimen, previous medical history, and presence of polypharmacy.
摘要
患者在面对安全治疗选择时常常面临挑战。一位 89 岁女性，有心律失常和难治性胃轻瘫病史，因使用苯二氮䓬类药物出现药物不良反应。在使用先进的临床决策支持系统进行全面药物审查和药物安全审查时，药剂师成功地将苯二氮䓬类药物逐渐减少到一种更安全的替代抗抑郁药，该药物被批准用于治疗胃轻瘫。根据她的年龄、当前药物治疗方案、既往病史和同时使用多种药物的情况，特别注意选择 QT 延长风险较低的药物。
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