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一种用于生命科学应用的混合微流控电子传感平台。

A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications.

作者信息

Panahi Abbas, Ghafar-Zadeh Ebrahim

机构信息

Biologically Inspired Sensors and Actuators (BioSA) Laboratory, Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J1P3, Canada.

出版信息

Micromachines (Basel). 2022 Mar 10;13(3):425. doi: 10.3390/mi13030425.

DOI:10.3390/mi13030425
PMID:35334717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8950014/
Abstract

This paper presents a novel hybrid microfluidic electronic sensing platform, featuring an electronic sensor incorporated with a microfluidic structure for life science applications. This sensor with a large sensing area of 0.7 mm is implemented through a foundry process called Open-Gate Junction FET (OG-JFET). The proposed OG-JFET sensor with a back gate enables the charge by directly introducing the biological and chemical samples on the top of the device. This paper puts forward the design and implementation of a PDMS microfluidic structure integrated with an OG-JFET chip to direct the samples toward the sensing site. At the same time, the sensor's gain is controlled with a back gate electrical voltage. Herein, we demonstrate and discuss the functionality and applicability of the proposed sensing platform using a chemical solution with different pH values. Additionally, we introduce a mathematical model to describe the charge sensitivity of the OG-JFET sensor. Based on the results, the maximum value of transconductance gain of the sensor is ~1 mA/V at Vgs = 0, which is decreased to ~0.42 mA/V at Vgs = 1, all in Vds = 5. Furthermore, the variation of the back-gate voltage from 1.0 V to 0.0 V increases the sensitivity from ~40 mV/pH to ~55 mV/pH. As per the experimental and simulation results and discussions in this paper, the proposed hybrid microfluidic OG-JFET sensor is a reliable and high-precision measurement platform for various life science and industrial applications.

摘要

本文提出了一种新型的混合微流控电子传感平台，其特点是将电子传感器与微流控结构相结合，用于生命科学应用。这种具有0.7平方毫米大传感面积的传感器是通过一种名为开栅结场效应晶体管（OG-JFET）的代工工艺实现的。所提出的带有背栅的OG-JFET传感器通过直接在器件顶部引入生物和化学样品来实现电荷注入。本文提出了一种与OG-JFET芯片集成的PDMS微流控结构的设计与实现，以将样品引导至传感部位。同时，通过背栅电压控制传感器的增益。在此，我们使用不同pH值的化学溶液展示并讨论了所提出的传感平台的功能和适用性。此外，我们引入了一个数学模型来描述OG-JFET传感器的电荷灵敏度。基于结果，在Vds = 5时，传感器跨导增益的最大值在Vgs = 0时约为1 mA/V，在Vgs = 1时降至约0.42 mA/V。此外，背栅电压从1.0 V变化到0.0 V时，灵敏度从约40 mV/pH增加到约55 mV/pH。根据本文的实验、模拟结果及讨论，所提出的混合微流控OG-JFET传感器是用于各种生命科学和工业应用的可靠且高精度的测量平台。

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