Service de Réanimation Néonatale et Néonatologie, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69677 Bron, France.
Réanimation Pédiatrique et Médecine Néonatale, CHU Félix Guyon, 97405 Saint Denis de la Réunion, France.
Nutrients. 2022 Mar 8;14(6):1145. doi: 10.3390/nu14061145.
We aimed to investigate whether the participation in an observational study on breastfeeding (Doal) modified breastfeeding outcomes in enrolling neonatal intensive care units (NICUs). This bi-centric before-and-after study included neonates who were admitted during a 4-month period before and a 4-month period after the implementation of Doal. Breastfeeding intention and breastfeeding rates at discharge were compared between the two periods. The association between inclusion in Doal and breastfeeding at discharge was assessed among the infants fulfilling the inclusion criteria of Doal. The present study included 655 neonates. After adjustments, both breastfeeding (aOR 1.21, 95%CI [1.1; 1.4], p = 0.001) and exclusive breastfeeding (aOR 1.8, 95%CI [1.4; 2.3], p < 0.001) at discharge increased in the period after. Breastfeeding intention was higher in one center in the period after (79%) compared to before (59%, p = 0.019). Compared to the period before, neonates who were not included in Doal in the period after had a lower chance to be breastfed at discharge, whereas those included were more frequently exclusively breastfed. The participation in an observational study on breastfeeding was associated with an increase in breastfeeding outcomes in enrolling neonatal intensive care units (NICUs). Patients who are not included deserve attention as they are at risk to be disadvantaged regarding breastfeeding success.
我们旨在研究参与母乳喂养观察性研究（Doal）是否会改变入组新生儿重症监护病房（NICU）的母乳喂养结果。这项双中心前后研究纳入了在实施 Doal 前 4 个月和后 4 个月期间入院的新生儿。比较了两个时期的出院时母乳喂养意向和母乳喂养率。在符合 Doal 纳入标准的婴儿中，评估了纳入 Doal 与出院时母乳喂养的相关性。本研究共纳入 655 名新生儿。调整后，出院时母乳喂养（aOR 1.21，95%CI [1.1; 1.4]，p = 0.001）和纯母乳喂养（aOR 1.8，95%CI [1.4; 2.3]，p < 0.001）的比例均增加。与前一时期相比，后一时期一个中心的出院时母乳喂养意向更高（79%），而前一时期为 59%（p = 0.019）。与前一时期相比，后一时期未纳入 Doal 的新生儿出院时母乳喂养的可能性较低，而纳入的新生儿更常进行纯母乳喂养。参与母乳喂养观察性研究与入组新生儿重症监护病房（NICU）的母乳喂养结果增加相关。未被纳入的患者应引起关注，因为他们在母乳喂养成功方面存在劣势风险。
