Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Department of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu 610041, China.
Nutrients. 2022 Mar 9;14(6):1160. doi: 10.3390/nu14061160.
With the prevalence of obesity all over the world, human health has been seriously affected. In particular, the number of diabetic and cardiovascular diseases has increased dramatically. The herb () shows diverse biological and pharmacological activities, which are mainly attributed to its flavonoids. However, the specific functional substances that play an active role in remain unclear, and its mechanism has not been deeply explored. In this study, we established a diet-induced obesity (DIO) mice model and treated mice with or kaempferol for 8 weeks. The results showed that both and kaempferol lowered body weight, reduced fasting blood glucose, and improved glucose tolerance and insulin resistance to alleviate obesity in DIO mice. The level of hemoglobin A1c also decreased significantly after treatment with and kaempferol. Moreover, the administration of and kaempferol also restored gut microbiota imbalance and significantly increased and levels, which have been reported to improve glucose metabolism and intestinal health. In general, our study shows that is a potential hypoglycemic substance for obesity and may reduce blood glucose by regulating gut microbiota, and that kaempferol is one of the effective substances of .
随着全球肥胖症的流行，人类健康受到了严重影响。特别是糖尿病和心血管疾病的数量急剧增加。该草药（）表现出多种生物和药理活性，主要归因于其类黄酮。然而，发挥积极作用的特定功能物质仍不清楚，其机制也未得到深入探讨。在本研究中，我们建立了饮食诱导肥胖（DIO）小鼠模型，并使用（）或山奈酚处理小鼠 8 周。结果表明，（）和山奈酚均降低了体重，降低了空腹血糖，并改善了葡萄糖耐量和胰岛素抵抗，从而缓解了 DIO 小鼠的肥胖。治疗后血红蛋白 A1c 水平也明显下降。此外，（）和山奈酚的给药还恢复了肠道微生物群失衡，并显著增加了（）和（）的水平，据报道，这可以改善葡萄糖代谢和肠道健康。总的来说，我们的研究表明，（）是一种有肥胖症治疗潜力的降血糖物质，可能通过调节肠道微生物群来降低血糖，而山奈酚是（）的有效物质之一。
