Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Nutrients. 2022 Mar 13;14(6):1216. doi: 10.3390/nu14061216.
Cystic fibrosis has historically been characterized by malnutrition, and nutrition strategies have placed emphasis on weight gain due to its association with better pulmonary outcomes. As treatment for this disease has significantly improved, longevity has increased and overweight and obesity have emerged issues in this population. The effect of excess weight and adiposity on CF clinical outcomes is unknown but may produce similar health consequences and obesity-related diseases as those observed in the general population. This review examines the prevalence of overweight and obesity in CF, the medical and psychological impact, as well as the existing evidence for treatment in the general population and how this may be applied to people with CF. Clinicians should partner with individuals with CF and their families to provide a personalized, interdisciplinary approach that includes dietary modification, physical activity, and behavioral intervention. Additional research is needed to identify the optimal strategies for preventing and addressing overweight and obesity in CF.
囊性纤维化历来以营养不良为特征，由于其与更好的肺部预后相关，营养策略一直侧重于体重增加。随着这种疾病的治疗有了显著改善，患者的寿命延长了，超重和肥胖已成为该人群的问题。超重和肥胖对 CF 临床结果的影响尚不清楚，但可能会产生与普通人群中观察到的类似的健康后果和与肥胖相关的疾病。本文综述了 CF 患者中超重和肥胖的流行情况、对医疗和心理的影响，以及在普通人群中治疗的现有证据，以及如何将这些证据应用于 CF 患者。临床医生应与 CF 患者及其家属合作，提供个性化的、跨学科的方法，包括饮食调整、身体活动和行为干预。需要进一步研究以确定预防和解决 CF 中超重和肥胖的最佳策略。
