Kim Byoung Hoon, Yoo Myung Chul
Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University Hospital, 23 Kyung Hee Dae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Vaccines (Basel). 2022 Feb 25;10(3):362. doi: 10.3390/vaccines10030362.
Inoculation with the Pfizer-BioNTech coronavirus infection-19 (COVID-19) vaccine (BNT162b2) has been approved in Korea. Although it is generally safe, several possible side effects have been reported. The present report describes a 28-year-old woman who developed an intracerebral hemorrhage in her right temporal lobe after the first dose of the Pfizer-BioNTech COVID-19 vaccine. The patient complained of a persistent headache for four days after the first dose, along with right third nerve palsy and drowsiness. Non-enhanced brain computed tomography confirmed a 5.0 × 3.7 × 5.0 cm-sized intracranial hemorrhage in the right temporal lobe due to the rupture of an arteriovenous malformation (AVM). Transfemoral cerebral angiography revealed that blood was supplied to the AVM by the right middle cerebral artery branch and drained into the right transverse sinus. The patient underwent surgical treatment for AVM nidus removal with hematoma evacuation on the day of admission. Her condition stabilized 10 days postoperatively. These findings indicate that clinicians should be aware that cerebral hemorrhage caused by AVM rupture may be a side effect of inoculation with the BNT162b2 mRNA COVID-19 vaccine.
辉瑞 - 生物科技公司的冠状病毒感染19（COVID - 19）疫苗（BNT162b2）接种已在韩国获得批准。尽管该疫苗总体上是安全的，但已有一些可能的副作用报告。本报告描述了一名28岁女性，在接种第一剂辉瑞 - 生物科技公司COVID - 19疫苗后，右侧颞叶发生脑出血。患者在接种第一剂疫苗后持续头痛四天，伴有右侧动眼神经麻痹和嗜睡。脑部非增强计算机断层扫描证实，由于动静脉畸形（AVM）破裂，右侧颞叶有一个5.0×3.7×5.0厘米大小的颅内出血。经股动脉脑血管造影显示，AVM由右侧大脑中动脉分支供血，并引流至右侧横窦。患者在入院当天接受了手术治疗，切除AVM病灶并清除血肿。术后10天她的病情稳定。这些发现表明，临床医生应意识到，AVM破裂导致的脑出血可能是接种BNT162b2 mRNA COVID - 19疫苗的一种副作用。
