Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitätsstr. 5-7, 45117 Essen, Germany.
Organic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitätsstr. 5-7, 45117 Essen, Germany.
Molecules. 2022 Mar 9;27(6):1788. doi: 10.3390/molecules27061788.
Three different alkyne-terminated aggregation-induced emission molecules based on a -substituted di-thioether were attached to the surface of ultrasmall gold nanoparticles (2 nm) by copper-catalyzed azide-alkyne cycloaddition (click chemistry). They showed a strong fluorescence and were well water-dispersible, in contrast to the dissolved AIE molecules. The AIE-loaded nanoparticles were not cytotoxic and easily penetrated the membrane of HeLa cells, paving the way for an intracellular application of AIE molecules, e.g., for imaging.
三种不同的炔基末端聚集诱导发光分子基于取代的二硫醚连接到超小的金纳米粒子（2nm）表面通过铜催化的叠氮-炔环加成（点击化学）。与溶解的 AIE 分子相比，它们表现出强烈的荧光和良好的水分散性。负载 AIE 的纳米粒子没有细胞毒性，很容易穿透 HeLa 细胞的细胞膜，为 AIE 分子的细胞内应用铺平了道路，例如用于成像。
