Davies H, Stroobant J, Leakey T, Helms P
Eur J Pediatr. 1986 Sep;145(4):258-9. doi: 10.1007/BF00439396.
The therapeutic effects of either morning or evening administration of a once-daily controlled release theophylline preparation (Uniphyllin) were studied in 17 asthmatic children. Neither morning nor evening administration produced therapeutic plasma theophylline levels throughout 24h. Similarly, bronchodilation was not maintained during the same period. However, morning peak expiratory flow rates were significantly improved following evening dosage, suggesting a role for evening administration when nocturnal symptoms predominate.
对17名哮喘儿童研究了每日一次控释茶碱制剂（优喘平）晨服或晚服的治疗效果。晨服和晚服在24小时内均未产生治疗性的血浆茶碱水平。同样，在此期间支气管扩张也未得到维持。然而，晚服后早晨的呼气峰值流速显著改善，提示在夜间症状占主导时晚服有一定作用。
