Nerminathan V, McKenzie S A
Arch Dis Child. 1984 Aug;59(8):762-5. doi: 10.1136/adc.59.8.762.
Twenty four hour profiles of serum theophylline concentrations were examined in 15 asthmatic children taking a new theophylline preparation once a day. Peak concentrations occurred at a time when nocturnal wheezing is likely. Fluctuation in concentrations throughout the day was greater than with other currently available preparations, but the importance of this has yet to be determined.
对15名每日服用一种新型茶碱制剂的哮喘儿童进行了血清茶碱浓度的24小时监测。峰值浓度出现在夜间可能出现喘息的时候。与目前其他可用制剂相比,全天浓度波动更大,但这一情况的重要性尚未确定。