每日一次服用茶碱；血清浓度。
Once a day theophylline; serum concentrations.
作者信息
Nerminathan V, McKenzie S A
出版信息
Arch Dis Child. 1984 Aug;59(8):762-5. doi: 10.1136/adc.59.8.762.
Abstract
Twenty four hour profiles of serum theophylline concentrations were examined in 15 asthmatic children taking a new theophylline preparation once a day. Peak concentrations occurred at a time when nocturnal wheezing is likely. Fluctuation in concentrations throughout the day was greater than with other currently available preparations, but the importance of this has yet to be determined.
摘要
对15名每日服用一种新型茶碱制剂的哮喘儿童进行了血清茶碱浓度的24小时监测。峰值浓度出现在夜间可能出现喘息的时候。与目前其他可用制剂相比，全天浓度波动更大，但这一情况的重要性尚未确定。
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本文引用的文献
1
Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children.
Pediatrics. 1980 Jul;66(1):97-102.
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Intrasubject variation in sustained-release theophylline absorption.
J Allergy Clin Immunol. 1981 Jun;67(6):465-71. doi: 10.1016/0091-6749(81)90100-7.
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Sustained-release theophylline for childhood asthma: evidence for circadian variation of theophylline pharmacokinetics.缓释型茶碱用于儿童哮喘：茶碱药代动力学昼夜变化的证据
J Pediatr. 1981 Sep;99(3):476-9. doi: 10.1016/s0022-3476(81)80354-x.
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Theophylline toxicity and viral infections.茶碱中毒与病毒感染
Pediatrics. 1982 Sep;70(3):508-9.
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Sustained-release theophylline: a significant advance in the treatment of childhood asthma.缓释茶碱：儿童哮喘治疗的一项重大进展。
J Pediatr. 1982 Mar;100(3):489-92. doi: 10.1016/s0022-3476(82)80467-8.
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Sustained-release theophylline. Pharmacokinetic and therapeutic comparison of two preparations.缓释茶碱。两种制剂的药代动力学和治疗学比较。
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Br Med J (Clin Res Ed). 1981 Jul 4;283(6283):18. doi: 10.1136/bmj.283.6283.18.
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