Canillas Maria, de Lima Gabriel Goetten, de Sá Marcelo J C, Nugent Michael J D, Rodríguez Miguel A, Devine Declan M
Consejo Superior de Investigaciones Cientificas, Instituto de Cerámica y Vidrio, Calle Kelsen, 5, 28049 Madrid, Spain.
Programa de Pós-Graduação em Engenharia e Ciência dos Materiais-PIPE, Universidade Federal do Paraná, Av. Cel. Francisco H. dos Santos, 100, Jardim das Américas, Curitiba 81530-000, Brazil.
Polymers (Basel). 2022 Mar 21;14(6):1261. doi: 10.3390/polym14061261.
The photocatalytic behaviours of semiconductive ceramic nanoparticles such as TiO, ZnO, FeO, and FeO, have been extensively studied in photocatalysis and photopolymerization, due to their ability to produce radical species under ultraviolet-visible light, and even in dark conditions. In addition, in the form of microparticles, TiO and its Magnéli phases are capable of neutralizing radical species, and a heterogeneous catalytic process has been suggested to explain this property, as it is well known as scavenging activity. Thus, in this study, we demonstrate that these ceramic powders, in the form of microparticles, could be used as photoinitiators in UV polymerization in order to synthesize a hydrogel matrix. Them, embedded ceramic powders could be able to neutralize radical species of physiological media once implanted. The hydrogel matrix would regulate the exchange of free radicals in any media, while the ceramic particles would neutralize the reactive species. Therefore, in this work, the scavenger activities of TiO, ZnO, FeO, and FeO microparticles, along with their photoinitiation yield, were evaluated. After photopolymerization, the gel fraction and swelling behaviour were evaluated for each hydrogel produced with different ceramic initiators. Gel fractions were higher than 60%, exhibiting variation in their scavenging activity. Therefore, we demonstrate that ceramic photoinitiators of TiO, ZnO, FeO, and FeO can be used to fabricate implantable devices with scavenger properties in order to neutralize radical species involved in inflammatory processes and degenerative diseases.
诸如TiO、ZnO、FeO和FeO等半导体陶瓷纳米颗粒的光催化行为，因其在紫外-可见光下甚至在黑暗条件下产生自由基物种的能力，已在光催化和光聚合领域得到广泛研究。此外，以微粒形式存在的TiO及其马格涅利相能够中和自由基物种，并且有人提出了一种非均相催化过程来解释这一特性，因为它具有众所周知的清除活性。因此，在本研究中，我们证明这些微粒形式的陶瓷粉末可作为紫外光聚合中的光引发剂，以合成水凝胶基质。然后，植入后嵌入的陶瓷粉末能够中和生理介质中的自由基物种。水凝胶基质将调节任何介质中自由基的交换，而陶瓷颗粒将中和反应性物种。因此，在这项工作中，评估了TiO、ZnO、FeO和FeO微粒的清除活性及其光引发产率。光聚合后，对用不同陶瓷引发剂制备的每种水凝胶的凝胶分数和溶胀行为进行了评估。凝胶分数高于60%，其清除活性存在差异。因此，我们证明TiO、ZnO、FeO和FeO的陶瓷光引发剂可用于制造具有清除特性的可植入装置，以中和参与炎症过程和退行性疾病的自由基物种。
