Zhou Yiguo, Zhou Xinyi, Lin Yi-Fan, Luo Ganfeng, Lu Yong, Wang Zhenyu, Li Peiyang, Luo Zhenzhou, Meng Xiaojun, Tian Tian, Fu Leiwen, Dai Jianghong, Zou Huachun
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
School of Public Health, Sun Yat-sen University, Guangzhou 510006, China.
Pathogens. 2022 Mar 3;11(3):314. doi: 10.3390/pathogens11030314.
(1) Background: We conducted a prospective observational cohort study to measure incidence, persistence, and clearance of anal human papillomavirus (HPV) among men who have sex with men (MSM) in China. (2) Methods: MSM were recruited in Guangzhou, Shenzhen and Wuxi, China in 2017. A tablet-based questionnaire was used to collect sociodemographic and behavioral characteristics. An anal brush sample was collected for HPV testing and genotyping. Participants were followed up 12 months after enrolment. (3) Results: A total of 196 participants completed two HPV tests with a median age of 27.3 (interquartile range (IQR) 24.0-32.8) years. Rate of incidence, persistence, and clearance for HPV among MSM were 31.3 (95% confidence interval (CI) 24.7-39.2), 47.9 (36.8-61.3), and 122.5 (104.3-143.0) per 1000 person months (pm), respectively. HPV 16 (4.1/1000 pm) had the highest incidence rate, and HPV 6 (47.4/1000 pm) had the highest persistence rate. Having lower education and engaging in receptive anal intercourse were potential risk factors of HPV incidence. A higher incidence rate was observed among younger MSM. (4) Conclusions: The high incidence and low clearance of anal HPV highlight the necessity of HPV vaccination among MSM. Further studies are needed to clarify the HPV dynamics at multiple anatomical sites and the burden of HPV-related diseases among MSM.
（1）背景：我们开展了一项前瞻性观察队列研究，以测量中国男男性行为者（MSM）中肛门人乳头瘤病毒（HPV）的发病率、持续感染率和清除率。（2）方法：2017年在中国广州、深圳和无锡招募MSM。使用基于平板电脑的问卷收集社会人口统计学和行为特征。采集肛门刷样本进行HPV检测和基因分型。参与者在入组后随访12个月。（3）结果：共有196名参与者完成了两次HPV检测，中位年龄为27.3岁（四分位间距（IQR）24.0 - 32.8岁）。MSM中HPV的发病率、持续感染率和清除率分别为每1000人月（pm）31.3（95%置信区间（CI）24.7 - 39.2）、47.9（36.8 - 61.3）和122.5（104.3 - 143.0）。HPV 16（4.1/1000 pm）的发病率最高，HPV 6（47.4/1000 pm）的持续感染率最高。受教育程度较低和进行接受性肛交是HPV感染的潜在危险因素。年轻的MSM中观察到较高的发病率。（4）结论：肛门HPV的高发病率和低清除率凸显了MSM中HPV疫苗接种的必要性。需要进一步研究以阐明多个解剖部位的HPV动态变化以及MSM中HPV相关疾病的负担。
