Ruwizhi Ngonidzashe, Maseko Rejoice Bethusile, Aderibigbe Blessing Atim
Department of Chemistry, University of Fort Hare, Alice Campus, Alice, Eastern Cape 5700, South Africa.
Department of Chemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa 0208, South Africa.
Pharmaceutics. 2022 Feb 25;14(3):504. doi: 10.3390/pharmaceutics14030504.
Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.
青蒿琥酯是一种半合成青蒿素衍生物，广为人知并被用作治疗疟疾的一线药物。除了治疗疟疾外，还发现青蒿琥酯对多种癌症和病毒具有生物活性。它还具有抗糖尿病、抗炎、抗动脉粥样硬化、免疫抑制等活性。在给药过程中，青蒿琥酯可以单独或与其他治疗剂一起负载于脂质体中。给药途径包括胃内、静脉内、口服和肠胃外给药。青蒿琥酯的生物活性基于其调节某些生物途径的能力。本手稿报道了对青蒿琥酯治疗效果最新进展的批判性综述。
