Ivanova Nadezhda, Sotirova Yoana, Gavrailov Georgi, Nikolova Krastena, Andonova Velichka
Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria.
Department of Physics and Biophysics, Faculty of Pharmacy, Medical University of Varna, 55 Marin Drinov Str., 9000 Varna, Bulgaria.
Pharmaceutics. 2022 Feb 27;14(3):530. doi: 10.3390/pharmaceutics14030530.
In this time of COVID-19 pandemic, the strategies for prevention of the infection are a primary concern. Looking more globally on the subject and acknowledging the high degree of misuse of protective face masks from the population, we focused this review on alternative pharmaceutical developments eligible for self-defense against respiratory infections. In particular, the attention herein is directed to the nasal and oromucosal formulations intended to boost the local immunity, neutralize or mechanically "trap" the pathogens at the site of entry (nose or mouth). The current work presents a critical review of the contemporary methods of immune- and chemoprophylaxis and their suitability and applicability in topical mucosal dosage forms for SARS-CoV-2 prophylaxis.
在新冠疫情期间，感染预防策略是首要关注点。从更宏观的角度看待这个问题，并认识到民众对防护口罩的滥用程度很高，我们将本次综述聚焦于适用于自我防御呼吸道感染的替代药物研发。特别是，本文重点关注旨在增强局部免疫力、在病原体进入部位（鼻子或口腔）中和或机械“捕获”病原体的鼻腔和口腔黏膜制剂。当前的工作对免疫预防和化学预防的当代方法及其在用于预防新冠病毒的局部黏膜剂型中的适用性和实用性进行了批判性综述。
