Gupta Anuradha, Lee Jungmi, Ghosh Torsha, Nguyen Van Quy, Dey Anup, Yoon Been, Um Wooram, Park Jae Hyung
School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 16419, Korea.
Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.
Pharmaceutics. 2022 Feb 28;14(3):540. doi: 10.3390/pharmaceutics14030540.
Rheumatoid arthritis (RA) and osteoarthritis (OA) are disabling musculoskeletal disorders that affect joints and cartilage and may lead to bone degeneration. Conventional delivery of anti-arthritic agents is limited due to short intra-articular half-life and toxicities. Innovations in polymer chemistry have led to advancements in hydrogel technology, offering a versatile drug delivery platform exhibiting tissue-like properties with tunable drug loading and high residence time properties This review discusses the advantages and drawbacks of polymeric materials along with their modifications as well as their applications for fabricating hydrogels loaded with therapeutic agents (small molecule drugs, immunotherapeutic agents, and cells). Emphasis is given to the biological potentialities of hydrogel hybrid systems/micro-and nanotechnology-integrated hydrogels as promising tools. Applications for facile tuning of therapeutic drug loading, maintaining long-term release, and consequently improving therapeutic outcome and patient compliance in arthritis are detailed. This review also suggests the advantages, challenges, and future perspectives of hydrogels loaded with anti-arthritic agents with high therapeutic potential that may alter the landscape of currently available arthritis treatment modalities.
类风湿性关节炎（RA）和骨关节炎（OA）是使人致残的肌肉骨骼疾病，会影响关节和软骨，并可能导致骨质退化。由于关节内半衰期短和毒性问题，传统的抗关节炎药物递送方式受到限制。聚合物化学的创新推动了水凝胶技术的进步，提供了一个多功能的药物递送平台，该平台具有类似组织的特性，药物负载量可调节且具有高驻留时间特性。本文综述了聚合物材料及其改性的优缺点，以及它们在制备负载治疗剂（小分子药物、免疫治疗剂和细胞）的水凝胶方面的应用。重点介绍了水凝胶杂化系统/微纳技术集成水凝胶作为有前景工具的生物学潜力。详细阐述了在关节炎中实现治疗药物负载的轻松调节、维持长期释放以及从而改善治疗效果和患者依从性的应用。本文还提出了负载具有高治疗潜力的抗关节炎药物的水凝胶的优势、挑战和未来前景，这些水凝胶可能会改变当前可用的关节炎治疗方式的格局。
