Bagel Arthur, Sergentet Delphine
'Bacterial Opportunistic Pathogens and Environment' Research Team, Université de Lyon, UMR5557 Ecologie Microbienne Lyon, CNRS (National Center of Scientific Research), VetAgro Sup, Marcy-l'Etoile, 69280 Lyon, France.
Laboratoire d'Etudes des Microorganismes Alimentaires Pathogènes-French National Reference Laboratory for Escherichia coli Including Shiga Toxin-Producing E. coli (NRL-STEC), VetAgro Sup-Campus Vétérinaire, Université de Lyon, Marcy-l'Etoile, 69280 Lyon, France.
Microorganisms. 2022 Feb 23;10(3):496. doi: 10.3390/microorganisms10030496.
Shiga toxin-producing (STEC) are zoonotic Gram-negative bacteria. While raw milk cheese consumption is healthful, contamination with pathogens such as STEC can occur due to poor hygiene practices at the farm level. STEC infections cause mild to serious symptoms in humans. The raw milk cheese-making process concentrates certain milk macromolecules such as proteins and milk fat globules (MFGs), allowing the intrinsic beneficial and pathogenic microflora to continue to thrive. MFGs are surrounded by a biological membrane, the milk fat globule membrane (MFGM), which has a globally positive health effect, including inhibition of pathogen adhesion. In this review, we provide an update on the adhesion between STEC and raw MFGs and highlight the consequences of this interaction in terms of food safety, pathogen detection, and therapeutic development.
产志贺毒素大肠杆菌（STEC）是一种人畜共患的革兰氏阴性菌。虽然食用生乳奶酪有益健康，但由于农场层面卫生措施不当，可能会出现STEC等病原体污染的情况。STEC感染会在人类身上引发从轻微到严重的症状。生乳奶酪制作过程会浓缩某些牛奶大分子，如蛋白质和乳脂肪球（MFGs），使内在的有益微生物群和致病微生物群得以继续生长。乳脂肪球被一层生物膜即乳脂肪球膜（MFGM）所包围，该膜对健康具有全面的积极影响，包括抑制病原体黏附。在本综述中，我们提供了关于STEC与未加工的MFGs之间黏附的最新情况，并强调了这种相互作用在食品安全、病原体检测和治疗开发方面的后果。
