心率变异性作为腹膜转移小鼠模型中癌痛的潜在指标。
Heart Rate Variability as a Potential Indicator of Cancer Pain in a Mouse Model of Peritoneal Metastasis.
机构信息
Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Biomedical Research Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02791, Korea.
出版信息
Sensors (Basel). 2022 Mar 10;22(6):2152. doi: 10.3390/s22062152.
Heart rate variability (HRV) is closely related to changes in the autonomic nervous system (ANS) associated with stress and pain. In this study, we investigated whether HRV could be used to assess cancer pain in mice with peritoneal metastases. At 12 days after cancer induction, positive indicators of pain such as physiological characteristics, appearance, posture, and activity were observed, and time- and frequency-domain HRV parameters such as mean R-R interval, square root of the mean squared differences of successive R-R intervals, and percentage of successive R-R interval differences greater than 5 ms, low frequency (LF), high frequency (HF), and ratio of LF and HF power, were found to be significantly decreased. These parameters returned to normal after analgesic administration. Our results indicate that overall ANS activity was decreased by cancer pain and that HRV could be a useful tool for assessing pain.
心率变异性（HRV）与与应激和疼痛相关的自主神经系统（ANS）变化密切相关。在这项研究中，我们研究了 HRV 是否可用于评估患有腹膜转移的小鼠的癌症疼痛。在癌症诱导后 12 天，观察到疼痛的阳性指标，如生理特征、外观、姿势和活动，并且发现时间和频率域 HRV 参数，如平均 R-R 间隔、连续 R-R 间隔均方差的平方根和大于 5 毫秒的连续 R-R 间隔差异的百分比、低频（LF）、高频（HF）和 LF 与 HF 功率的比值均显著降低。这些参数在镇痛给药后恢复正常。我们的结果表明，癌症疼痛会导致整体 ANS 活动降低，而 HRV 可能是评估疼痛的有用工具。
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