Gill Pavandeep, Aung Phyu P
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.
Department of Laboratory Medicine, Vancouver Island Health Authority, Victoria, BC V8R 1J8, Canada.
Biology (Basel). 2022 Mar 17;11(3):460. doi: 10.3390/biology11030460.
Deep penetrating nevus (DPN) is an uncommon acquired melanocytic lesion with a distinct histopathological appearance that typically behaves in an indolent manner. The lesion is characterized by a symmetrical proliferation of epithelioid to spindled melanocytes associated with abundant melanophages and wedge-shaped extension to the deep reticular dermis and subcutis. Pronounced cytologic atypia and mitotic figures are usually absent, which helps distinguish DPN from melanoma with a deep penetrating growth pattern. Recently, the concept of atypical DPN has been proposed for lesions that demonstrate borderline histomorphologic features and may be associated with lymph node deposits but lack the copy number aberrations typical of melanoma by either fluorescence in situ hybridization or comparative genomic hybridization. While most of these lesions have a favorable clinical course, rare lesions may progress to melanoma. In this review, we summarize the current literature on atypical DPNs with uncertain behavior/metastatic potential and outline the characteristics that distinguish these lesions from conventional DPN and melanoma with DPN-like features.
深部浸润性痣（DPN）是一种罕见的后天性黑素细胞病变，具有独特的组织病理学表现，通常生长缓慢。该病变的特征是上皮样至梭形黑素细胞呈对称性增殖，伴有大量噬黑素细胞，并呈楔形延伸至深部网状真皮和皮下组织。通常不存在明显的细胞异型性和有丝分裂象，这有助于将DPN与具有深部浸润性生长模式的黑色素瘤区分开来。最近，对于表现出临界组织形态学特征且可能与淋巴结转移有关，但通过荧光原位杂交或比较基因组杂交缺乏黑色素瘤典型拷贝数畸变的病变，提出了非典型DPN的概念。虽然这些病变大多临床过程良好，但罕见病变可能进展为黑色素瘤。在本综述中，我们总结了目前关于行为/转移潜能不确定的非典型DPN的文献，并概述了将这些病变与传统DPN以及具有DPN样特征的黑色素瘤区分开来的特征。
