Homer Natalie A, Rieger Kerri E
Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Departments of Dermatology and Pathology, Stanford University, Palo Alto, CA, USA.
Am J Ophthalmol Case Rep. 2024 Apr 16;34:102059. doi: 10.1016/j.ajoc.2024.102059. eCollection 2024 Jun.
The term melanocytoma was recently proposed for intermediate-stage melanocytic lesions with specific histopathologic and molecular genetic features. Prior studies have demonstrated a heightened potential for these intermediate lesions to spread to regional lymph nodes, with decreased likelihood for distant spread, when compared to melanomas.
Herein we present a case of a 28-year-old male who presented with a recurrent right lower eyelid margin combined cutaneous and palpebral conjunctival pigmented lesion, ultimately classified as a melanocytoma, to highlight this new nomenclature, characteristic histopathologic and genetic findings, and prognostic implications.
Ophthalmologists should be aware of this new cutaneous histopathologic classification system and apply to the periorbital region to improve melanocytic lesion management and surveillance.
术语“黑素细胞瘤”最近被用于描述具有特定组织病理学和分子遗传学特征的中期黑素细胞性病变。先前的研究表明，与黑色素瘤相比，这些中期病变扩散至区域淋巴结的可能性增加，远处转移的可能性降低。
在此，我们报告一例28岁男性患者，其右下睑缘复发性皮肤及睑结膜色素沉着性病变，最终被分类为黑素细胞瘤，以突出这种新的命名法、特征性组织病理学和遗传学发现以及预后意义。
眼科医生应了解这种新的皮肤组织病理学分类系统，并将其应用于眶周区域，以改善黑素细胞性病变的管理和监测。
