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意大利北部旅游胜地特伦托省新冠疫情的起源与传播情况

On the Origin and Propagation of the COVID-19 Outbreak in the Italian Province of Trento, a Tourist Region of Northern Italy.

作者信息

Bianco Luca, Moser Mirko, Silverj Andrea, Micheletti Diego, Lorenzin Giovanni, Collini Lucia, Barbareschi Mattia, Lanzafame Paolo, Segata Nicola, Pindo Massimo, Franceschi Pietro, Rota-Stabelli Omar, Rizzoli Annapaola, Fontana Paolo, Donati Claudio

机构信息

Research and Innovation Centre, Fondazione Edmund Mach, Via Mach 1, 38098 San Michele all'Adige, Italy.

Centro Alimentazione, Agricoltura e Ambiente, Università degli Studi di Trento, 38098 San Michele all'Adige, Italy.

出版信息

Viruses. 2022 Mar 11;14(3):580. doi: 10.3390/v14030580.

DOI:10.3390/v14030580
PMID:35336987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8951735/
Abstract

BACKGROUND

Trentino is an Italian province with a tourism-based economy, bordering the regions of Lombardy and Veneto, where the two earliest and largest outbreaks of COVID-19 occurred in Italy. The earliest cases in Trentino were reported in the first week of March 2020, with most of the cases occurring in the winter sport areas in the Dolomites mountain range. The number of reported cases decreased over the summer months and was followed by a second wave in the autumn and winter of 2020.

METHODS

we performed high-coverage Oxford Nanopore sequencing of 253 positive SARS-CoV-2 swabs collected in Trentino between March and December 2020.

RESULTS

in this work, we analyzed genome sequences to trace the routes through which the virus entered the area, and assessed whether the autumnal resurgence could be attributed to lineages persisting undetected during summer, or as a consequence of new introductions.

CONCLUSIONS

Comparing the draft genomes analyzed with a large selection of European sequences retrieved from GISAID we found that multiple introductions of the virus occurred at the early stage of the epidemics; the two epidemic waves were unrelated; the second wave was due to reintroductions of the virus in summer when traveling restrictions were uplifted.

摘要

背景

特伦蒂诺是意大利的一个省份，经济以旅游业为主，与伦巴第和威尼托地区接壤，意大利最早和最大规模的两起新冠疫情就发生在这两个地区。特伦蒂诺最早的病例于2020年3月的第一周报告，大多数病例发生在多洛米蒂山脉的冬季运动区。报告病例数在夏季有所下降，随后在2020年秋冬出现了第二波疫情。

方法

我们对2020年3月至12月期间在特伦蒂诺采集的253份新冠病毒阳性拭子进行了高覆盖率的牛津纳米孔测序。

结果

在这项工作中，我们分析了基因组序列，以追踪病毒进入该地区的途径，并评估秋季疫情复发是否可归因于夏季未被检测到而持续存在的谱系，或者是新传入的结果。

结论

将分析的草图基因组与从全球共享流感数据倡议组织（GISAID）检索到的大量欧洲序列进行比较，我们发现病毒在疫情早期有多次传入；两波疫情没有关联；第二波疫情是由于夏季旅行限制解除时病毒的再次传入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/3fc20c7556f4/viruses-14-00580-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/44679484f369/viruses-14-00580-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/83834dc71f26/viruses-14-00580-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/47498397fc84/viruses-14-00580-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/3fc20c7556f4/viruses-14-00580-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/44679484f369/viruses-14-00580-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/83834dc71f26/viruses-14-00580-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/47498397fc84/viruses-14-00580-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5411/8951735/3fc20c7556f4/viruses-14-00580-g004.jpg

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