Institute of Medical Microbiology and Virology, Medical Faculty, Technische Universität Dresden, Dresden, Saxony, Germany.
Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Saxony, Germany.
Epidemiol Infect. 2021 Jul 30;149:e177. doi: 10.1017/S0950268821001461.
In Germany, Eastern regions had a mild first wave of coronavirus disease 2019 (COVID-19) from March to May 2020, but were badly hit by a second wave later in autumn and winter. It is unknown how the second wave was initiated and developed in Eastern Germany where the number of COVID-19 cases was close to zero in June and July 2020. We used genomic epidemiology to investigate the dynamic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage development across the first and second waves in Eastern Germany. With detailed phylogenetic analyses we could show that SARS-CoV-2 lineages prevalent in the first and second waves in Eastern Germany were different, with several new variants including four predominant lineages in the second wave, having been introduced into Eastern Germany between August and October 2020. The results indicate that the major driving force behind the second wave was the introduction of new variants.
在德国，东部地区 2020 年 3 月至 5 月经历了 2019 年冠状病毒病（COVID-19）的第一波温和疫情，但在秋季和冬季遭遇了第二波严重疫情。目前尚不清楚在 COVID-19 病例数量在 2020 年 6 月和 7 月接近零的东德，第二波疫情是如何开始和发展的。我们使用基因组流行病学来研究在东德的第一波和第二波 COVID-19 疫情中严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）谱系的发展动态。通过详细的系统发育分析，我们可以表明，在东德的第一波和第二波疫情中流行的 SARS-CoV-2 谱系不同，在第二波疫情中有几个新的变体，包括 2020 年 8 月至 10 月间传入东德的 4 个主要谱系。结果表明，第二波疫情的主要驱动力是新变体的引入。
Nat Med. 2021-3
J Med Virol. 2020-3-27
PLoS Negl Trop Dis. 2020-11-30
J Virol. 2021-1-13
Nat Microbiol. 2020-7-15
Bioinformatics. 2018-12-1
Virus Evol. 2018-1-8
Euro Surveill. 2017-3-30
Zotero 插件