Spoială Angela, Ilie Cornelia-Ioana, Ficai Denisa, Ficai Anton, Andronescu Ecaterina
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gh Polizu Street, 011061 Bucharest, Romania.
National Centre for Micro and Nanomaterials and National Centre for Food Safety, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania.
Pharmaceuticals (Basel). 2022 Mar 7;15(3):318. doi: 10.3390/ph15030318.
In the past year, researchers have focused their attention on developing new strategies for understanding how the coronavirus affects human health and developing novel biomaterials to help patients with cardiovascular disease, which greatly increases the risk of complications from the virus. Natural biopolymers have been investigated, and it has been proven that alginate-based materials have important features. This review presents an overview of alginate-based materials used for developing innovative biomaterial platforms for biomedical applications to mitigate the effects of the coronavirus. As presented in this review, COVID-19 affects the cardiovascular system, not only the lungs. The first part of the review presents an introduction to cardiovascular diseases and describes how they have become an important problem worldwide. In the second part of the review, the origin and unique properties of the alginate biopolymer are presented. Among the properties of alginate, the most important are its biocompatibility, biodegradability, low cost, nontoxicity, unique structure, and interesting features after chemical modification. The third section of the review illustrates some of the functions of alginate in biomedical, pharmaceutical, and drug delivery applications. Researchers are using alginate to develop new devices and materials for repairing heart tissues that have been damaged by the coronavirus. Further, insights regarding how cardiovascular disease affects COVID-19 patients are also discussed. Finally, we conclude the review by presenting a summary of the impacts of COVID-19 on cardiovascular patients, their implications, and several hypothetical alginate-based treatments for infected patients.
在过去的一年里，研究人员将注意力集中在开发新策略上，以了解冠状病毒如何影响人类健康，并开发新型生物材料来帮助患有心血管疾病的患者，因为心血管疾病会大大增加感染该病毒后出现并发症的风险。天然生物聚合物已得到研究，事实证明基于藻酸盐的材料具有重要特性。本综述概述了用于开发创新生物材料平台以减轻冠状病毒影响的基于藻酸盐的材料，这些平台用于生物医学应用。如本综述所述，COVID-19不仅影响肺部，还会影响心血管系统。综述的第一部分介绍了心血管疾病，并描述了它们如何成为全球范围内的一个重要问题。在综述的第二部分，介绍了藻酸盐生物聚合物的起源和独特性质。在藻酸盐的性质中，最重要的是其生物相容性、生物可降解性、低成本、无毒性、独特结构以及化学修饰后的有趣特性。综述的第三部分阐述了藻酸盐在生物医学、制药和药物递送应用中的一些功能。研究人员正在使用藻酸盐开发新的设备和材料，用于修复因冠状病毒而受损的心脏组织。此外，还讨论了心血管疾病如何影响COVID-19患者的相关见解。最后，我们通过总结COVID-19对心血管疾病患者的影响、其影响因素以及几种基于藻酸盐的针对感染患者的假设性治疗方法来结束本综述。
