Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Vietnam.
Nat Prod Res. 2023 Jul-Aug;37(15):2559-2567. doi: 10.1080/14786419.2022.2056182. Epub 2022 Mar 25.
Sixteen sesquiterpenoids including two new ones, homalolides A - B ‒, were firstly isolated from the methanolic extract of the rhizomes of collected in Vietnam. The structures and relative stereochemistry of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses. The GCMS experiment demonstrated that homalolide A () is an artifact due to the methylation during methanolic extraction process. All isolates (‒) were tested for their inhibitory activities against lipopolysaccharide-induced nitric oxide production in the RAW 264.7 macrophage cell line. Compounds , , ‒, ‒ displayed moderate inhibitory effect on NO production with IC values ranging from 35.41 to 64.06 μM.
十六种倍半萜类化合物，包括两种新化合物，即 homalolide A 和 B，首次从越南采集的根茎的甲醇提取物中分离得到。新化合物的结构和相对立体化学通过 1D-/2D-NMR、IR、UV 和 HRESIMS 分析阐明。GCMS 实验表明，homalolide A（）是由于甲醇提取过程中甲基化而产生的一种假象。所有分离物（‒）均测试了其对 RAW 264.7 巨噬细胞系中脂多糖诱导的一氧化氮产生的抑制活性。化合物 、 、 、 对 NO 产生具有中等抑制作用，IC 值范围为 35.41 至 64.06 μM。
