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大鼠硬脑膜中神经降压素的分布及其与头痛和免疫系统的可能功能。

Distribution and possible function of galanin about headache and immune system in the rat dura mater.

机构信息

Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Sendai, 980-8575, Japan.

出版信息

Sci Rep. 2022 Mar 25;12(1):5206. doi: 10.1038/s41598-022-09325-3.

DOI:10.1038/s41598-022-09325-3
PMID:35338230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8956595/
Abstract

Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In this study, GAL expression was investigated in the rat dura mater to demonstrate its possible function in headache using immunohistochemical techniques. The cerebral falx and cerebellar dura mater received abundant blood and nerve supply, and were significantly thicker compared to other portions in the cerebral dura mater. GAL-immunoreactivity was expressed by cell and nerve fiber profiles. Presumed macrophages and dendritic cells contained GAL-immunoreactivity, and co-expressed with CD11b-immunoreactivity. Many isolated and perivascular nerve fibers also showed GAL-immunoreactivity. In addition, GAL-immunoreactive nerve fibers were present in the vicinity of macrophages and dendritic cells with either GAL- or ED1-immunoreactivity. GAL-immunoreactive cells and nerve fibers were common in the cerebral falx and cerebellar dura mater and infrequent in other portions. And, GAL-immunoreactive nerve fibers usually co-expressed calcitonin gene-related peptide (CGRP)-immunoreactivity. In the trigeminal ganglion, a substantial proportion of sensory neurons innervating the dura mater contained GAL-immunoreactivity (mean ± SD, 3.4 ± 2.2%), and co-expressed CGRP-immunoreactivity (2.7 ± 2.1%). The present study may suggest that GAL is associated with nociceptive transduction or modulation in the dura mater. GAL also possibly plays a role in the immune mechanism of the dura mater.

摘要

神经节甘丙肽（GAL）是三叉感觉系统中的一种伤害性递质或调质。本研究采用免疫组织化学技术，研究大鼠硬脑膜中 GAL 的表达，以探讨其在头痛中的可能作用。大脑镰和小脑硬脑膜接受丰富的血液和神经供应，与大脑硬脑膜的其他部位相比，明显更厚。GAL 免疫反应性由细胞和神经纤维轮廓表达。推测巨噬细胞和树突状细胞含有 GAL 免疫反应性，并与 CD11b 免疫反应性共表达。许多分离的和血管周围的神经纤维也显示出 GAL 免疫反应性。此外，GAL 免疫反应性神经纤维存在于巨噬细胞和树突状细胞附近，这些细胞要么含有 GAL 免疫反应性，要么含有 ED1 免疫反应性。GAL 免疫反应性细胞和神经纤维在大脑镰和小脑硬脑膜中很常见，而在其他部位则很少见。并且，GAL 免疫反应性神经纤维通常与降钙素基因相关肽（CGRP）免疫反应性共表达。在三叉神经节中，支配硬脑膜的感觉神经元中有相当一部分含有 GAL 免疫反应性（平均值±标准差，3.4±2.2%），并与 CGRP 免疫反应性共表达（2.7±2.1%）。本研究提示 GAL 与硬脑膜中的伤害性转导或调制有关。GAL 可能在硬脑膜的免疫机制中发挥作用。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0634/8956595/0f232c0da288/41598_2022_9325_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0634/8956595/a749eb478127/41598_2022_9325_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0634/8956595/0f232c0da288/41598_2022_9325_Fig7_HTML.jpg

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