Turk J Med Sci. 2023 Feb;53(1):366-373. doi: 10.55730/1300-0144.5593. Epub 2023 Feb 22.
Data on adverse prognostic factors for mortality in patients with dementia with Lewy bodies (DLB) are limited. The objective of this study was to evaluate two-year mortality predictors in patients with DLB.
: Individuals aged ≥ 60 years with a diagnosis of DLB, followed by a tertiary-referral geriatric outpatient clinic from 2006 to 2021, were assessed retrospectively using medical or patient records. The mortality status of the patients in the second year after diagnosis was determined. Demographic and clinical characteristics were reviewed to determine their impact on mortality prediction.
A total of 108 patients with DLB participated in this study. The mean age was 78.9 ± 6.6 years, and 49.1% were females. At the end of the two-year follow-up, 23 patients (21.3%) died and 85 patients (78.7%) were still alive. Malnutrition, and cognitive and functional impairments were significantly more common in the mortality group. Age, female sex, functional impairment, moderateto-severe clinical dementia rating, and malnutrition were associated with an increased mortality risk. On the multivariable analysis, malnutrition (HR = 5.00; 95% CI: 1.64-15.24; p: 0.005) was the only independent predictor of two-year-mortality.
Patients with DLB had an unfavorable survival outcomes. Approaches to prevent malnutrition can improve prognosis and reduce early mortality in this vulnerable group. However, further studies are needed to determine mortality risk factors in this population.
关于路易体痴呆（DLB）患者死亡率的不良预后因素的数据有限。本研究旨在评估 DLB 患者两年死亡率的预测因素。
回顾性评估了 2006 年至 2021 年在三级转诊老年门诊就诊的年龄≥60 岁、诊断为 DLB 的个体的医疗或患者记录。确定了患者在诊断后第二年的死亡状态。评估了人口统计学和临床特征，以确定它们对死亡率预测的影响。
共有 108 例 DLB 患者参与了这项研究。平均年龄为 78.9±6.6 岁，49.1%为女性。在两年的随访结束时，23 名患者（21.3%）死亡，85 名患者（78.7%）仍然存活。营养不良以及认知和功能障碍在死亡组中更为常见。年龄、女性、功能障碍、中重度临床痴呆评定量表和营养不良与死亡风险增加相关。多变量分析显示，营养不良（HR=5.00；95%CI：1.64-15.24；p：0.005）是两年死亡率的唯一独立预测因素。
DLB 患者的生存结果不佳。预防营养不良的方法可以改善该脆弱人群的预后并降低早期死亡率。但是，需要进一步的研究来确定该人群的死亡率危险因素。
