Pang Li, Dai Yawen, Ren Fang, Peng Xu, Guo Zhiqiang
Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shen Yang, China.
Curr Med Imaging. 2022;18(10):1125-1131. doi: 10.2174/1573405618666220325095615.
Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare neoplasms with unknown etiology. This type of tumor has low malignant potential and mostly manifests as a benign clinical course.
This article analyzes the case data, clinical manifestations, and histopathological characteristics of two cases of UTROSCT, and reviews the relevant literature. The diagnosis of UTROSCT is mainly based on histopathological examination. The histological characteristics of granulosa and Sertoli cell tumours are similar to the ovary under the microscope. These cases' clinical and radiological (MRI) findings have also been discussed.
The sex cord components are mixed in different proportions. The immunohistochemistry is diverse and can express sex cord markers together with both epithelial and smooth muscle markers. Both two cases revealed the signs of intratumoral cystic degeneration, intratumoral hemorrhage, and necrosis under MRI. These MRI features were helpful to prompt UTROSCT, which is histologically similar to granular cell tumors and is conducive to the differential diagnosis.
The current recommended treatment is total hysterectomy, but its biological behavior is not yet clear, and long-term follow-up is needed.
子宫性索样肿瘤（UTROSCT）是一种病因不明的罕见肿瘤。这类肿瘤恶性潜能低，临床过程多表现为良性。
本文分析了2例UTROSCT的病例资料、临床表现及组织病理学特征，并复习相关文献。UTROSCT的诊断主要基于组织病理学检查。显微镜下，颗粒细胞瘤和支持细胞瘤的组织学特征与卵巢相似。还讨论了这些病例的临床及影像学（MRI）表现。
性索成分以不同比例混合。免疫组化表现多样，可同时表达性索标记物以及上皮和平滑肌标记物。2例在MRI下均显示瘤内囊性变、瘤内出血及坏死征象。这些MRI特征有助于提示UTROSCT，其在组织学上与颗粒细胞瘤相似，有利于鉴别诊断。
目前推荐的治疗方法是全子宫切除术，但其生物学行为尚不清楚，需要长期随访。
