N-亚硝基化合物形成的DNA加合物
DNA adducts by N-nitroso compounds.
作者信息
Wiessler M
出版信息
J Cancer Res Clin Oncol. 1986;112(2):81-4. doi: 10.1007/BF00404386.
Abstract
Some unsolved problems in DNA alkylation by N-nitroso compounds are discussed in this overview. Does O6 alkylation of guanine represent the initiating event exclusively or are O4 alkylation of thymidine and phosphate triester formation also involved in the initiating process? Does the formation of rearranged DNA alkylation products by longer chained alkylnitroso compounds have any significance for the carcinogenic effects of these compounds? The concept of hard and soft acids and bases (HSAB principle) as a qualitative model can predict the changes in the DNA alkylation pattern by branched carbenium ions.
摘要
本综述讨论了N-亚硝基化合物使DNA烷基化过程中一些尚未解决的问题。鸟嘌呤的O6烷基化是否仅代表起始事件，或者胸腺嘧啶的O4烷基化和磷酸三酯的形成是否也参与起始过程？长链烷基亚硝基化合物形成的重排DNA烷基化产物对这些化合物的致癌作用有何意义？软硬酸碱概念（HSAB原理）作为一种定性模型，可以预测支链碳正离子引起的DNA烷基化模式的变化。
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