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Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.

作者信息

Pegg A E

出版信息

Cancer Invest. 1984;2(3):223-31. doi: 10.3109/07357908409104376.

DOI:10.3109/07357908409104376
PMID:6733565
Abstract
摘要

相似文献

1
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.DNA中鸟嘌呤O6位的甲基化是甲基化剂致癌过程中最可能的起始事件。
Cancer Invest. 1984;2(3):223-31. doi: 10.3109/07357908409104376.
2
The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis.
Mutat Res. 1985 Jan-Mar;145(1-2):1-16. doi: 10.1016/0167-8817(85)90034-3.
3
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.鸟嘌呤O6位的烷基化只是众多可能引发致癌作用的化学事件之一。
Cancer Invest. 1984;2(3):233-8. doi: 10.3109/07357908409104377.
4
Relationships between DNA adduct formation and carcinogenesis.DNA加合物形成与致癌作用之间的关系。
Environ Health Perspect. 1985 Oct;62:177-83. doi: 10.1289/ehp.8562177.
5
[Molecular mechanisms of the adaptive response to alkylating agents].[对烷化剂适应性反应的分子机制]
Biochimie. 1985 Oct-Nov;67(10-11):IX-XIV. doi: 10.1016/s0300-9084(85)80094-8.
6
The contribution of O6-methylguanine and methylphosphotriesters to the cytotoxicity of alkylating agents in mammalian cells.O6-甲基鸟嘌呤和甲基磷酸三酯对烷化剂在哺乳动物细胞中细胞毒性的作用。
Carcinogenesis. 1988 Sep;9(9):1587-93. doi: 10.1093/carcin/9.9.1587.
7
Repair of DNA alkylation adducts in mammalian cells.哺乳动物细胞中DNA烷基化加合物的修复
Biochimie. 1985 Sep;67(9):919-28. doi: 10.1016/s0300-9084(85)80288-1.
8
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability.在缺乏和具备DNA修复蛋白O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的细胞中，烷基化诱变剂对c-fos、c-jun、junB和junD信使核糖核酸（mRNA）及活化蛋白-1（AP-1）的诱导作用及其与细胞死亡、诱变和染色体不稳定性的关系。
Oncogene. 1996 Nov 7;13(9):1927-35.
9
Demethylation of O6-methylguanine in DNA by O6-methylguanine-DNA methyltransferase: synthesis and characterization of O6,9-dimethylguanine coordinated with cis-platin at the N7-position.O6-甲基鸟嘌呤-DNA甲基转移酶对DNA中O6-甲基鸟嘌呤的去甲基化作用：N7位与顺铂配位的O6,9-二甲基鸟嘌呤的合成与表征。
Chem Pharm Bull (Tokyo). 1994 Apr;42(4):903-6. doi: 10.1248/cpb.42.903.
10
Structural studies of O6-methyldeoxyguanosine and related compounds: a promutagenic DNA lesion by methylating carcinogens.O6-甲基脱氧鸟苷及相关化合物的结构研究：甲基化致癌物导致的一种前诱变DNA损伤
Nucleic Acids Res. 1988 Oct 11;16(19):9307-21. doi: 10.1093/nar/16.19.9307.

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Profiling of ribonucleotides and deoxyribonucleotides pools in response to DNA damage and repair induced by methyl methanesulfonate in cancer and normal cells.在癌症细胞和正常细胞中，对甲磺酸甲酯诱导的DNA损伤和修复过程中核糖核苷酸池和脱氧核糖核苷酸池的分析。
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DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.DNA烷化剂可预防自发性肝细胞癌，与O6-甲基鸟嘌呤-DNA甲基转移酶状态无关。
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