Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
Department of Nursing, Meiho University, Pingtung, Taiwan.
Psychiatry Clin Neurosci. 2022 Jul;76(7):303-308. doi: 10.1111/pcn.13357. Epub 2022 Apr 13.
Individuals with substance use disorders (SUD) have higher risk of developing pain disorders. This study aimed to investigate the risk of major psychiatric disorders (MPD), SUD, and pain disorders among their offspring.
This study used data from the Taiwan National Health Research Database. The case cohort included participants who had a parent diagnosed with SUD. The matched control cohort was offspring of parents without any SUD or major psychiatric disorder (MPD). Poisson regression was applied to estimate the risk of MPD, SUD, and pain disorder between case and control cohorts.
We recruited 13,840 cases and 138,400 matched controls. After adjusting for demographic characteristics and family history of psychiatric disorder, the offspring of parents with SUD had higher risk for bipolar disorder (reported as risk ratio with 95% confidence interval: 2.48, 1.79-3.43), depressive disorder (2.22, 1.94-2.52), SUD (2.53, 2.18-2.92), and alcohol use disorder (1.43, 1.16-1.76) than controls. With adjustments of demographic characteristics, individual MPD, and family history of psychiatric disorder, they also presented higher risk than controls for several pain disorders, including migraine (1.43, 1.15-1.78), fibromyalgia (1.21, 1.03-1.42), dorsopathies (1.20, 1.06-1.37), dysmenorrhea (1.16, 1.04-1.29), irritable bowel syndrome (1.26, 1.11-1.43), and dyspepsia (1.14, 1.02-1.27).
Clinicians should be aware of the influence of parental SUD on the elevated risk for MPD, SUD, and pain disorders in their offspring.
患有物质使用障碍（SUD）的个体发生疼痛障碍的风险较高。本研究旨在调查其子女发生主要精神障碍（MPD）、SUD 和疼痛障碍的风险。
本研究使用了来自台湾国家健康研究数据库的数据。病例队列包括有父母被诊断为 SUD 的参与者。匹配的对照组是父母无任何 SUD 或主要精神障碍（MPD）的子女。应用泊松回归估计病例队列和对照组之间 MPD、SUD 和疼痛障碍的风险。
我们招募了 13840 例病例和 138400 例匹配对照。在调整人口统计学特征和精神障碍家族史后，SUD 父母的子女发生双相障碍（报告为风险比及其 95%置信区间：2.48，1.79-3.43）、抑郁障碍（2.22，1.94-2.52）、SUD（2.53，2.18-2.92）和酒精使用障碍（1.43，1.16-1.76）的风险高于对照组。在调整人口统计学特征、个体 MPD 和精神障碍家族史后，他们发生几种疼痛障碍的风险也高于对照组，包括偏头痛（1.43，1.15-1.78）、纤维肌痛（1.21，1.03-1.42）、背病（1.20，1.06-1.37）、痛经（1.16，1.04-1.29）、肠易激综合征（1.26，1.11-1.43）和消化不良（1.14，1.02-1.27）。
临床医生应意识到父母 SUD 对其子女发生 MPD、SUD 和疼痛障碍风险升高的影响。
