Ruffatti A, Peserico A, Glorioso S, Fiocco U, Rossi L, Gambari P, Todesco S
J Am Acad Dermatol. 1986 Oct;15(4 Pt 1):637-42. doi: 10.1016/s0190-9622(86)70217-x.
Using metaphase chromosome spreads as substrate for indirect immunofluorescence technic, we observed anticentromere antibody in three of twenty-five patients affected with various clinical forms of localized scleroderma. Anticentromere antibody is generally considered a serologic marker of the CREST syndrome, a more benign subset of systemic sclerosis. However, none of the three anticentromere antibody-positive patients with localized scleroderma had Raynaud's phenomenon, acrosclerosis, or any signs or symptoms of systemic disease; on physical and laboratory examination, they showed only typical cutaneous features of localized scleroderma: two showed linear scleroderma, and one showed localized morphea. A 2-year 8-month follow-up of two patients did not disclose any clinical evidence of systemic sclerosis. The occurrence of anticentromere antibody in patients with localized scleroderma seems to offer supportive evidence that a relationship exists between localized scleroderma and systemic sclerosis.
以中期染色体铺片为间接免疫荧光技术的底物，我们在25例患有各种临床类型局限性硬皮病的患者中的3例中观察到了抗着丝点抗体。抗着丝点抗体通常被认为是CREST综合征的血清学标志物，CREST综合征是系统性硬化症中一种相对良性的亚型。然而，这3例局限性硬皮病抗着丝点抗体阳性的患者均无雷诺现象、肢端硬化或任何系统性疾病的体征或症状；体格检查和实验室检查显示，他们仅表现出局限性硬皮病的典型皮肤特征：2例表现为线状硬皮病，1例表现为局限性硬斑病。对2例患者进行了2年8个月的随访，未发现任何系统性硬化症的临床证据。局限性硬皮病患者中抗着丝点抗体的出现似乎为局限性硬皮病与系统性硬化症之间存在关联提供了支持性证据。
