Department of Reproductive Medicine, Qingdao University Affiliated Yantai Yuhuangding Hospital, Yantai, Shangdong 264000, China.
J Healthc Eng. 2022 Mar 16;2022:9467568. doi: 10.1155/2022/9467568. eCollection 2022.
To explore the intracytoplasmic sperm injection (ICSI) and fertilization (IVF) method on the clinical outcomes of infertile women with ≤3 eggs retrieved. We retrospectively analyzed a cohort of female patients who received IVF/ICSI to assist pregnancy with retrieved eggs ≤3. The general conditions, i.e., two pronuclei (2PN) fertilization rate, abnormal fertilization rate, high-quality embryo rate, cycle cancellation rate, pregnancy rate of fresh embryo transfer, cumulative pregnancy rate, and miscarriage were compared between the two groups.
When the number of retrieved eggs was one, the fertilization rate of 2PN was higher and the cycle cancellation rate was lower in the ICSI group than in the IVF group ( < 0.05). The pregnancy rates of fresh embryo transfer, frozen-thawed embryo transfer, and the cumulative pregnancy rate were all higher in the ICSI group than in the IVF group ( < 0.05). When the number of retrieved eggs was two, the pregnancy rate of frozen-thawed embryo transfer and cumulative pregnancy rate in the ICSI group were higher than those in the IVF group ( < 0.05). When the number of retrieved eggs was three, the fertilization rate of 2PN and the pregnancy rate of frozen-thawed embryo transfer were higher in the ICSI group than those in the IVF group (all ( < 0.05)).
For patients with one egg retrieved, ICSI fertilization can reduce abnormal fertilization rate and cycle cancellation rate and improve cumulative pregnancy rate significantly enhancing patients' benefits. However, increasing the number of eggs retrieved decreases the advantages of ICSI fertilization.
探讨卵母细胞数≤3 个的不孕妇女行卵胞浆内单精子注射（ICSI）受精对临床结局的影响。方法：回顾性分析了一组接受体外受精/卵胞浆内单精子注射（IVF/ICSI）助孕且获卵数≤3 的女性患者的临床资料。比较了两组患者的一般情况（如：2 原核（2PN）受精率、异常受精率、优质胚胎率、周期取消率、新鲜胚胎移植妊娠率、累计妊娠率和流产率。结果：当获卵数为 1 个时，ICSI 组的 2PN 受精率较高，周期取消率较低（<0.05）。ICSI 组新鲜胚胎移植、冻融胚胎移植和累计妊娠率均高于 IVF 组（<0.05）。当获卵数为 2 个时，ICSI 组的冻融胚胎移植妊娠率和累计妊娠率均高于 IVF 组（<0.05）。当获卵数为 3 个时，ICSI 组的 2PN 受精率和冻融胚胎移植妊娠率均高于 IVF 组（均<0.05）。结论：对于获卵数为 1 个的患者，ICSI 受精可显著降低异常受精率和周期取消率，提高累计妊娠率，从而提高患者的受益程度。然而，随着获卵数的增加，ICSI 受精的优势逐渐减少。
