Haas A A, Arndt K A
J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):870-7. doi: 10.1016/s0190-9622(86)70244-2.
Since topical retinoic acid was first used for acne in 1959, many additional uses have been described for lesions on the skin, oral mucosa, and ocular surface epithelia. The topical application of retinoic acid has been shown to be effective in the treatment of several disorders of keratinization, keloids and hypertrophic scars, and various infections and inflammatory, pigmentation, and malignant and premalignant disorders. This article briefly reviews the use of topical retinoic acid for selected cutaneous conditions.
自1959年局部用维甲酸首次用于治疗痤疮以来，人们又发现了它在治疗皮肤、口腔黏膜及眼表上皮病变方面的许多其他用途。维甲酸局部应用已被证明对治疗多种角化异常性疾病、瘢痕疙瘩和增生性瘢痕，以及各种感染性、炎症性、色素沉着性、恶性及癌前疾病有效。本文简要综述局部用维甲酸在某些皮肤病中的应用。
