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夏威夷原住民和/或波利尼西亚人中的颈椎后纵韧带骨化症(OPLL):一项为期 3 年的回顾性人口统计学和描述性初步研究。

Cervical Ossification of the Posterior Longitudinal Ligament (OPLL) in Native Hawaiians and/or Polynesians: A 3-year Retrospective Demographic and Descriptive Pilot Study.

机构信息

Department of Surgery, Division of Orthopaedics University of Hawai'i: University of Hawai'i Orthopaedics Residency Program, Honolulu, HI (MH, CW, JPL, KM).

Department of Orthopaedic surgery, Tripler Army Medical Center, Honolulu, HI (RB).

出版信息

Hawaii J Health Soc Welf. 2022 Mar;81(3 Suppl 1):8-12.

Abstract

Ossification of the posterior longitudinal ligament (OPLL) is a disease characterized by the replacement of the posterior longitudinal ligament with ectopic bone and cartilage. Historically, the disease was described as highly prevalent in Japanese and other Asian populations. However, recent studies suggest OPLL may have a higher prevalence in non-Asian communities than previously believed. To date, there are no demographic or epidemiologic studies examining OPLL in Native Hawaiian or Polynesian communities. The purpose of this study was to review the demographics and comorbidities of a cohort of patients with OPLL from the author's institution, designated as either Native Hawaiian and/or Polynesian (NHP) or Non-Native Hawaiian and/or Polynesian (NNHP). Demographic findings from this study were similar to previous literature demonstrating higher rates of OPLL in men and older patients with an average age of 56 years in the NHP group and 65 years in the NNHP group. There were no statistically significant differences in the rates of type II diabetes mellitus, coronary vascular disease, chronic kidney disease, or hypertension between NHP and NNHP groups. The NHP group exhibited statistically higher rates of obesity when compared to the NNHP group. Obesity's risk in the development or progression of OPLL in the NHP population has not been examined and requires additional investigation. This study serves as a beginning for further demographic and epidemiologic investigations into OPLL in Native Hawaiian and Polynesian communities to facilitate improved identification of those at risk and guide diagnosis and treatment of these patients.

摘要

骨化性后纵韧带(OPLL)是一种疾病,其特征是异位骨和软骨取代后纵韧带。历史上,该疾病在日本和其他亚洲人群中高度流行。然而,最近的研究表明,OPLL 在非亚洲人群中的患病率可能高于先前认为的。迄今为止,还没有针对夏威夷原住民或波利尼西亚社区的 OPLL 的人口统计学或流行病学研究。本研究的目的是回顾作者所在机构的一组 OPLL 患者的人口统计学和合并症,这些患者被指定为夏威夷原住民和/或波利尼西亚人(NHP)或非夏威夷原住民和/或波利尼西亚人(NNHP)。本研究的人口统计学发现与先前的文献相似,表明男性和老年患者的 OPLL 发病率更高,NHP 组的平均年龄为 56 岁,NNHP 组的平均年龄为 65 岁。NHP 组和 NNHP 组在 2 型糖尿病、冠心病、慢性肾脏病或高血压的发病率方面没有统计学差异。与 NNHP 组相比,NHP 组肥胖的发病率更高。肥胖在 NHP 人群中 OPLL 的发展或进展中的风险尚未得到检验,需要进一步研究。本研究为进一步对夏威夷原住民和波利尼西亚社区的 OPLL 进行人口统计学和流行病学研究奠定了基础,有助于更好地识别高危人群,并指导这些患者的诊断和治疗。

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本文引用的文献

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Ossification of the Posterior Longitudinal Ligament: Surgical Approaches and Associated Complications.
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Molecular Pathophysiology of Ossification of the Posterior Longitudinal Ligament (OPLL).
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Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification.
PLoS One. 2018 May 21;13(5):e0196204. doi: 10.1371/journal.pone.0196204. eCollection 2018.

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