DeBiasio Celina, Cyr Janelle, Petkiewicz Stephanie, Glassman Steven J
Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
SAGE Open Med Case Rep. 2022 Mar 22;10:2050313X221086321. doi: 10.1177/2050313X221086321. eCollection 2022.
Hypergammaglobulinemic purpura of Waldenström is an uncommon disease, which presents mostly in women on the lower extremities. It is sometimes associated with underlying immune dysregulation. Sjögren syndrome is the most common association; however, rare occurrences of the self-resolving syndrome with lymphoma or myeloma have been reported.
We describe an unusual and impressive presentation of hypergammaglobulinemic purpura of Waldenström in an elderly female patient with myeloma. Notably, the patient did not have any concurrent connective tissue diseases. Despite her florid presentation, her hypergammaglobulinemic purpura of Waldenström spontaneously resolved within a few days.
Hypergammaglobulinemic purpura of Waldenström is a self-resolving but recurrent syndrome, which may be associated with autoimmune disorders or rarely myeloma. Early diagnosis of the syndrome may avoid unnecessary treatment interventions and should prompt screening for underlying diseases.
瓦尔登斯特伦高球蛋白血症性紫癜是一种罕见疾病，主要见于女性下肢。它有时与潜在的免疫调节异常有关。干燥综合征是最常见的关联疾病；然而，也有报道称其罕见地会自行缓解，并伴有淋巴瘤或骨髓瘤。
我们描述了一位患有骨髓瘤的老年女性患者出现的不寻常且令人印象深刻的瓦尔登斯特伦高球蛋白血症性紫癜。值得注意的是，该患者没有任何并发的结缔组织疾病。尽管她症状明显，但她的瓦尔登斯特伦高球蛋白血症性紫癜在几天内自行缓解。
瓦尔登斯特伦高球蛋白血症性紫癜是一种可自行缓解但会复发的综合征，可能与自身免疫性疾病相关，或罕见地与骨髓瘤有关。该综合征的早期诊断可避免不必要的治疗干预，并应促使对潜在疾病进行筛查。
