Cheung V Y, Bocking A D, Hollomby D, Gagnon R, Walton J
Department of Obstetrics and Gynecology, University of Western Ontario, London, Canada.
Obstet Gynecol. 1993 Oct;82(4 Pt 2 Suppl):685-7.
Waldenström hypergammaglobulinemic purpura is characterized by hypergammaglobulinemia, recurring purpura, and an elevated erythrocyte sedimentation rate. It is a rare disease and, to our knowledge, there have been no previous reports of its presence during pregnancy. We report a patient with this disease whose pregnancy was complicated by severe fetal growth restriction (FGR) and acute fetal distress.
A 24-year-old primigravid woman with a history of Waldenström hypergammaglobulinemic purpura and renal insufficiency developed FGR at 32 weeks' gestation. Cesarean delivery was performed at 33.5 weeks because of acute fetal distress, and a 1305-g male infant was delivered. Neonatal outcome was successful. No deterioration of the woman's medical condition occurred during or after her pregnancy.
Successful pregnancy outcome is possible in women with Waldenström hypergammaglobulinemic purpura. In view of the risk of FGR, close monitoring of fetal growth and well-being is recommended in women with this condition.
华氏巨球蛋白血症性紫癜的特征为高球蛋白血症、复发性紫癜和红细胞沉降率升高。这是一种罕见疾病，据我们所知，此前尚无孕期出现该病的报道。我们报告一名患有此病的患者，其妊娠合并严重胎儿生长受限（FGR）和急性胎儿窘迫。
一名24岁初孕妇，有华氏巨球蛋白血症性紫癜和肾功能不全病史，在妊娠32周时出现FGR。由于急性胎儿窘迫，于33.5周行剖宫产，娩出一名体重1305克的男婴。新生儿结局良好。该妇女在孕期及产后病情均未恶化。
患有华氏巨球蛋白血症性紫癜的女性有可能获得成功的妊娠结局。鉴于存在FGR风险，建议对患有此病的女性密切监测胎儿生长及健康状况。
