Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA.
Program in Neuroscience, Indiana University, Bloomington, IN, USA.
Clin EEG Neurosci. 2023 Jul;54(4):409-419. doi: 10.1177/15500594221089367. Epub 2022 Mar 28.
The mismatch negativity (MMN) event-related potential (ERP) indexes relatively automatic detection of changes in sensory stimuli and is typically attenuated in individuals with schizophrenia. However, contributions of different frequencies of electroencephalographic (EEG) activity to the MMN and the later P3a attentional orienting response in schizophrenia are poorly understood and were the focus of the present study. Participants with a schizophrenia-spectrum disorder ( = 85) and non-psychiatric control participants ( = 74) completed a passive auditory oddball task containing 10% 50 ms "deviant" tones and 90% 100 ms "standard" tones. EEG data were analyzed using spatial principal component analysis (PCA) applied to wavelet-based time-frequency analysis and MMN and P3a ERPs. The schizophrenia group compared to the control group had smaller MMN amplitudes and lower deviant-minus-standard theta but not alpha event-related spectral perturbation (ERSP) after accounting for participant age and sex. Larger MMN and P3a amplitudes but not latencies were correlated with greater theta and alpha time-frequency activity. Multiple linear regression analyses revealed that control participants showed robust relationships between larger MMN amplitudes and greater deviant-minus-standard theta inter-trial coherence (ITC) and between larger P3a amplitudes and greater deviant-minus-standard theta ERSP, whereas these dynamic neural processes were less tightly coupled in participants with a schizophrenia-spectrum disorder. Study results help clarify frequency-based contributions of time-domain (ie, ERP) responses and indicate a potential disturbance in the neural dynamics of detecting change in sensory stimuli in schizophrenia. Overall, findings add to the growing body of evidence that psychotic illness is associated with widespread neural dysfunction in the theta frequency band.
失匹配负波（MMN）事件相关电位（ERP）指数可相对自动地检测感觉刺激的变化，且在精神分裂症患者中通常会减弱。然而，不同频率的脑电图（EEG）活动对 MMN 和精神分裂症中晚期 P3a 注意定向反应的贡献仍不清楚，这也是本研究的重点。 患有精神分裂症谱系障碍的参与者（ = 85）和非精神病性对照组参与者（ = 74）完成了一项被动听觉Oddball 任务，其中包含 10%的 50ms“偏差”音和 90%的 100ms“标准”音。使用基于小波的时频分析和 MMN 和 P3a ERP 对 EEG 数据进行空间主成分分析（PCA）分析。在考虑参与者年龄和性别后，与对照组相比，精神分裂症组的 MMN 振幅较小，偏差减去标准θ的事件相关光谱扰动（ERSP）较低，但α则没有。更大的 MMN 和 P3a 振幅但没有潜伏期与更大的θ和α时频活动相关。多元线性回归分析表明，对照组参与者的 MMN 振幅与更大的偏差减去标准θ的内trial 相干（ITC）之间以及 P3a 振幅与更大的偏差减去标准θ的 ERSP 之间存在很强的关系，而在患有精神分裂症谱系障碍的参与者中，这些动态神经过程的相关性较弱。研究结果有助于阐明时域（即 ERP）反应的基于频率的贡献，并表明在精神分裂症中，感觉刺激检测的神经动力学可能存在潜在干扰。总的来说，研究结果增加了越来越多的证据，即精神病与θ频带中的广泛神经功能障碍有关。
