Demeyere Nele, Williams Owen A, Milosevich Elise, Chiu Evangeline G, Drozdowska Bogna A, Dillon Avril, Dawes Helen, Thomas Shirley, Kuppuswamy Annapoorna, Pendlebury Sarah T, J Quinn Terence
Department of Experimental Psychology, University of Oxford, Oxford, UK.
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Eur Stroke J. 2021 Dec;6(4):428-437. doi: 10.1177/23969873211046120. Epub 2021 Oct 26.
The long-term psychological consequences of stroke and how cognitive problems change over time after the first-year following stroke remain unclear. Particularly, trajectories of domain-specific and domain-general cognitive functions and how cognition interacts with mood, fatigue and quality of life are not well described.
To determine the prevalence, trajectories and wider impact of domain-specific cognitive impairment in long-term stroke survivors, in relation to mood, fatigue and quality of life.
Participants who previously took part in the Oxford Cognitive Screening study, completed the 6-month follow-up with cognitive, mood, fatigue and quality of life assessments and agreed to be contacted for future research will be recruited into OX-CHRONIC. The eligible cohort is between 2- and 9-years post-stroke. Cognition will be assessed with a detailed neuropsychological battery, alongside questionnaire measures of mood, fatigue, activities of daily life and quality of life measures at two timepoints, 1 year apart. Additionally, medical records will be accessed to extract further clinical information about the stroke and patients may opt-in to wear an activity monitor for 1 week to provide fine-grained measures of sleep and activity. The study protocol and study materials were approved by the national ethics committee (REC Ref: 19/SC/0520).
OX-CHRONIC will provide detailed data on the evolving cognitive profiles of stroke survivors over several years post-stroke. Estimates of long-term prevalence as well as the effect of changes in cognitive profiles on mood, fatigue and quality of life will be examined. This study is funded by a Priority Programme Grant from the Stroke Association (SA PPA 18/100032).
中风的长期心理后果以及认知问题在中风后第一年之后如何随时间变化仍不清楚。特别是，特定领域和一般领域认知功能的轨迹以及认知与情绪、疲劳和生活质量之间的相互作用尚未得到充分描述。
确定长期中风幸存者中特定领域认知障碍的患病率、轨迹及其对情绪、疲劳和生活质量的更广泛影响。
曾参与牛津认知筛查研究、完成了为期6个月的认知、情绪、疲劳和生活质量评估随访且同意为未来研究接受联系的参与者将被纳入OX-CHRONIC研究。符合条件的队列是中风后2至9年。将使用详细的神经心理测试组评估认知，同时在相隔1年的两个时间点通过问卷测量情绪、疲劳、日常生活活动和生活质量。此外，将查阅病历以提取有关中风的更多临床信息，患者可以选择佩戴活动监测器1周，以提供关于睡眠和活动的细粒度测量。该研究方案和研究材料已获得国家伦理委员会批准（研究伦理委员会参考号：19/SC/0520）。
OX-CHRONIC研究将提供中风幸存者中风后数年认知状况演变的详细数据。将研究长期患病率估计以及认知状况变化对情绪、疲劳和生活质量的影响。本研究由中风协会的优先计划资助（SA PPA 18/100032）。
