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已鉴定出的人乳成分可有效抑制新冠病毒及其变体的感染和复制。

Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication.

作者信息

Lai Xinyuan, Yu Yanying, Xian Wei, Ye Fei, Ju Xiaohui, Luo Yuqian, Dong Huijun, Zhou Yi-Hua, Tan Wenjie, Zhuang Hui, Li Tong, Liu Xiaoyun, Ding Qiang, Xiang Kuanhui

机构信息

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

School of Medicine, Tsinghua University, Beijing 100084, China.

出版信息

iScience. 2022 Apr 15;25(4):104136. doi: 10.1016/j.isci.2022.104136. Epub 2022 Mar 22.

DOI:10.1016/j.isci.2022.104136
PMID:35342878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8937612/
Abstract

The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to public health. Human breast milk is a complex nutritional composition to nourish infants and protect them from different kinds of infectious diseases including COVID-19. Here, we identified that lactoferrin (LF), mucin1 (MUC1), and α-lactalbumin (α-LA) from human breast milk inhibit SARS-CoV-2 infection using a SARS-CoV-2 pseudovirus system and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). In addition, LF and MUC1 inhibited multiple steps including viral attachment, entry, and postentry replication, whereas α-LA inhibited viral attachment and entry. Importantly, LF, MUC1, and α-LA possess potent antiviral activities toward variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.1 (kappa). Taken together, our study provides evidence that human breast milk components (LF, MUC1, and α-LA) are promising antiviral and potential therapeutic candidates warranting further development for treating COVID-19.

摘要

由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染引起的新型冠状病毒肺炎全球大流行对公众健康构成了巨大威胁。人乳是一种复杂的营养成分，可滋养婴儿并保护他们免受包括新型冠状病毒肺炎在内的各种传染病的侵害。在此，我们使用SARS-CoV-2假病毒系统以及具有转录和复制能力的SARS-CoV-2病毒样颗粒（trVLP），确定了人乳中的乳铁蛋白（LF）、粘蛋白1（MUC1）和α-乳白蛋白（α-LA）可抑制SARS-CoV-2感染。此外，LF和MUC1抑制了包括病毒附着、进入和进入后复制在内的多个步骤，而α-LA抑制了病毒附着和进入。重要的是，LF、MUC1和α-LA对诸如B.1.1.7（阿尔法）、B.1.351（贝塔）、P.1（伽马）和B.1.617.1（卡帕）等变体具有强大的抗病毒活性。综上所述，我们的研究提供了证据，表明人乳成分（LF、MUC1和α-LA）是有前景的抗病毒和潜在治疗候选物，值得进一步开发用于治疗新型冠状病毒肺炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/688807eafa2c/gr8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/5d58cd98a7c8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/594da295d8ea/gr2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/688807eafa2c/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/67df8f05a4b8/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/5d58cd98a7c8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/594da295d8ea/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/5e0bbdcf5c31/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/397c5e1d98c9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/54149b1dfb88/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/cd3c87a72707/gr6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9112/8980811/688807eafa2c/gr8.jpg

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