2020 年 10 月至 11 月英国 SARS-CoV-2 N501Y 突变株的早期传播能力评估。
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020.
机构信息
WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, New Territories, Hong Kong SAR, China.
出版信息
Euro Surveill. 2021 Jan;26(1). doi: 10.2807/1560-7917.ES.2020.26.1.2002106.
Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.
两种具有受体结合域 N501Y 突变的新型 SARS-CoV-2 谱系在英国迅速传播。我们估计，早期的没有氨基酸缺失 Δ69/Δ70 的 501Y 谱系，主要在 9 月初至 11 月中旬之间传播，比 501N 谱系的传染性高 10%（6-13%），而自 9 月下旬以来传播的具有氨基酸缺失 Δ69/Δ70 的 501Y 谱系，比 501N 谱系的传染性高 75%（70-80%）。
Zotero 插件