College of Clinical Medicine, Jining Medical University, Jining, SD, China.
Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, SD, China.
Clin Exp Hypertens. 2022 May 19;44(4):334-340. doi: 10.1080/10641963.2022.2043891. Epub 2022 Mar 27.
At present, pre-eclampsia is a growing concern and still a diagnostic challenge for obstetricians.
This study aimed to evaluate whether the relationship of second trimester of pregnancy neutrophil count differed among pregnancies with mild preeclampsia, severe preeclampsia, and healthy status and explore whether or not neutrophil count in the second trimester of pregnancy would be useful as new predictors of subsequent preeclampsia.
This study involved 933 pregnancies from 1 January 2018 to 30 January 2021, comprising 396 healthy pregnancies, 222 pregnancies with mild preeclampsia, and 315 pregnancies with severe preeclampsia. The relationship between preeclampsia and neutrophil count was analyzed by multiple logistic regression. In addition, maternal placental tissues of three groups were immunohistochemically stained for myeloperoxidase (MPO).
Neutrophil count was significantly higher in pregnancies with preeclampsia (including pregnancies with mild and severe preeclampsia) than that in healthy pregnancies. The neutrophil count level was prominently higher in patients with severe preeclampsia compared with those with mild preeclampsia (p < .001). The neutrophil count level was significantly positively associated with preeclampsia after adjusting for gestational week at time of blood sampling, BMI, and age (β:1.23; 95%CI:1.09-1.36; p < .0001). In addition, MPO expressions of placental tissues in preeclamptic groups were significantly increased than these in healthy pregnant controls (p < .05).
Increased neutrophil count in the second trimester of pregnancy was significantly positively associated with preeclampsia. Hence, neutrophil count plays a role in predicting the severity of preeclampsia. At the same time, it may be an independent predictor of subsequent preeclampsia. BMI: body mass index; MPO: myeloperoxidase.
目前，子痫前期是产科医生越来越关注的问题，也是一个诊断挑战。
本研究旨在评估妊娠中期中性粒细胞计数在轻度子痫前期、重度子痫前期和健康状态的妊娠中是否存在差异，并探讨妊娠中期中性粒细胞计数是否可作为预测子痫前期的新指标。
本研究纳入了 2018 年 1 月 1 日至 2021 年 1 月 30 日的 933 例妊娠，包括 396 例健康妊娠、222 例轻度子痫前期妊娠和 315 例重度子痫前期妊娠。采用多因素逻辑回归分析子痫前期与中性粒细胞计数的关系。此外，三组孕妇的胎盘组织进行髓过氧化物酶（MPO）免疫组织化学染色。
子痫前期（包括轻度和重度子痫前期）孕妇的中性粒细胞计数明显高于健康孕妇。重度子痫前期患者的中性粒细胞计数水平明显高于轻度子痫前期患者（p<0.001）。在校正采血时的孕周、BMI 和年龄后，中性粒细胞计数水平与子痫前期显著正相关（β：1.23；95%CI：1.09-1.36；p<0.0001）。此外，子痫前期组胎盘组织的 MPO 表达明显高于健康孕妇对照组（p<0.05）。
妊娠中期中性粒细胞计数增加与子痫前期显著正相关。因此，中性粒细胞计数在预测子痫前期的严重程度方面发挥作用。同时，它可能是预测子痫前期的独立指标。BMI：体重指数；MPO：髓过氧化物酶。
