Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai, 200032, China.
Nuclear Medicine Institute of Fudan University, Shanghai, 200032, China.
Eur J Nucl Med Mol Imaging. 2022 Aug;49(10):3538-3546. doi: 10.1007/s00259-022-05772-2. Epub 2022 Mar 28.
To comparatively evaluate the diagnostic performances of total-body F-fluorodeoxyglucose positron-emission tomography/computed tomography (F-FDG PET/CT) with fast 2-min acquisition and conventional PET/CT in liver cancer patients.
This study included 156 patients with liver tumours. Seventy-eight patients underwent total-body PET/CT. PET raw data were reconstructed using acquisition durations of 2 min (G2) and 15 min (G15). Another 78 patients with liver lesions (control patients) underwent conventional uMI780 PET/CT (G780). All patients were evaluated based on TNM staging. The maximum tumour standardized uptake value (tumour SUVmax), mean normal liver SUV (SUVmean), and tumour SUVmax-to-liver SUVmean ratio (TLR) were determined for all patients. G15 data were used as the reference in the lesion detectability analysis. The diagnostic performances of PET/CT in terms of visual parameters and of PET in terms of semi-quantitative parameters such as SUVmax and TLR were evaluated. Receiver operating characteristics (ROC) curve analysis of SUVmax and TLR at G2 was performed. Pathologic findings of surgical specimens served as the gold standard for all patients.
The lesions found in G15 were also noted in G2; three lymph nodes were missed in G2. However, no significant difference was found in the TNM stage among G2, G15, and G780. For benign and malignant lesions, the liver SUVmean in G2 and G15 was higher than that in G780 (all P < 0.05). The tumour SUVmax and TLR in G2 were equivalent to those in G15 and G780 regardless of whether the lesions were benign or malignant. ROC curve analysis (SUVmax cutoff: 4.34, TLR cutoff: 1.34) demonstrated that G2 also had good sensitivity in detecting liver cancer.
The diagnostic performance of total-body PET/CT in G2 was comparable to that in G15 among liver cancer patients. Further, the diagnostic efficiency of total-body PET/CT imaging with fast 2-min acquisition and conventional PET/CT was similar.
比较全身 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）与常规 PET/CT 中 2 分钟快速采集和 15 分钟采集在肝癌患者中的诊断性能。
本研究纳入了 156 例肝脏肿瘤患者。其中 78 例患者行全身 PET/CT 检查。采集时长分别为 2 分钟（G2）和 15 分钟（G15）时，对 PET 原始数据进行重建。另 78 例肝脏病变患者（对照组）行常规 uMI780 PET/CT（G780）检查。所有患者均基于 TNM 分期进行评估。对所有患者测定最大肿瘤标准化摄取值（肿瘤 SUVmax）、正常肝脏平均 SUV（SUVmean）和肿瘤 SUVmax 与肝脏 SUVmean 比值（TLR）。在病变检出分析中，将 G15 数据作为参考。评估 PET/CT 的视觉参数和 PET 的半定量参数（SUVmax 和 TLR）的诊断性能。对 G2 的 SUVmax 和 TLR 进行受试者工作特征（ROC）曲线分析。所有患者均以手术标本的病理结果作为金标准。
G15 中发现的病灶也在 G2 中发现，G2 中遗漏了 3 个淋巴结。但 G2、G15 和 G780 之间的 TNM 分期无显著差异。对于良性和恶性病变，G2 和 G15 的肝脏 SUVmean 均高于 G780（均 P<0.05）。无论病变良恶性，G2 的肿瘤 SUVmax 和 TLR 与 G15 和 G780 相当。ROC 曲线分析（SUVmax 截断值：4.34，TLR 截断值：1.34）表明 G2 也具有良好的肝癌检出灵敏度。
在肝癌患者中，G2 全身 PET/CT 的诊断性能与 G15 相当。此外，快速 2 分钟采集和常规 PET/CT 的全身 PET/CT 成像的诊断效率相似。
