School of Medicine, University of Nottingham, Nottingham, UK.
Preventive Neurology Unit, Wolfson Institute of Population Health, London, EC1M 6BQ, UK.
J Neurol. 2022 Aug;269(8):4436-4439. doi: 10.1007/s00415-022-11085-z. Epub 2022 Mar 27.
To examine the relative risk of suicide mortality in patients with Huntington's disease (HD).
A case-control study design was used. We used linked electronic records from primary care, secondary care and Office for National Statistics from England from 2001 through 2019. Controls were matched to cases by general practice and suicide date. Odds ratios (ORs) were adjusted for gender and age at suicide/index date.
Data were available for 594,674 individuals. Patients with HD who died from suicide were significantly younger at time of death than patients with HD who died from causes other than suicide (p < 0.001). The adjusted OR for HD was 9.2 (95% confidence intervals, CI 4.9-17.4) compared to those without HD. The increase in risk was higher amongst the younger age group who were ≤ 45.8 years at suicide/index date (OR 54.5, 95% CI 10.8-276.1).
The markedly elevated suicide risk in patients with HD suggests that implementation of suicide risk assessment may improve survival in individuals with these diseases, especially in younger patients.
探讨亨廷顿病（HD）患者自杀死亡率的相对风险。
采用病例对照研究设计。我们使用了 2001 年至 2019 年英格兰初级保健、二级保健和国家统计局的电子记录进行链接。对照病例通过普通实践和自杀日期进行匹配。自杀/索引日期的性别和年龄调整了比值比（ORs）。
共获得 594674 名个体的数据。与因其他原因而非自杀死亡的 HD 患者相比，死于自杀的 HD 患者的死亡年龄明显较小（p<0.001）。与无 HD 患者相比，HD 的调整后 OR 为 9.2（95%置信区间，CI 4.9-17.4）。自杀/索引日期≤45.8 岁的年轻年龄组的风险增加更高（OR 54.5，95% CI 10.8-276.1）。
HD 患者自杀风险显著升高表明，实施自杀风险评估可能会提高这些疾病患者的生存率，尤其是在年轻患者中。
