Di Maio L, Squitieri F, Napolitano G, Campanella G, Trofatter J A, Conneally P M
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis.
J Med Genet. 1993 Apr;30(4):293-5. doi: 10.1136/jmg.30.4.293.
In order to evaluate the relevance of suicide risk in families affected by Huntington's disease (HD), 2793 subjects registered with the National Huntington's Disease Research Roster were studied. Suicide was the reported cause of death in 205 subjects (7.3%). This group included affected and possibly affected subjects, subjects at 50% and 25% risk, possibly at risk subjects, and normal relatives. In all categories suicide was more frequent than in the general US population. The data suggest that suicide is quite frequent in some families with HD. This increased suicide risk must be carefully considered in planning genetic counselling for predictive testing in HD.
为了评估亨廷顿舞蹈症（HD）患者家庭中自杀风险的相关性，我们对登记在国家亨廷顿舞蹈症研究名册上的2793名受试者进行了研究。205名受试者（7.3%）的死亡原因被报告为自杀。该组包括患病及可能患病的受试者、50%和25%风险水平的受试者、可能有风险的受试者以及正常亲属。在所有类别中，自杀发生率均高于美国普通人群。数据表明，在一些患有HD的家庭中，自杀相当常见。在为HD的预测性检测进行遗传咨询规划时，必须认真考虑这种增加的自杀风险。
