Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.
Department of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, 21205, USA.
Support Care Cancer. 2022 Jul;30(7):5769-5778. doi: 10.1007/s00520-022-07004-7. Epub 2022 Mar 26.
To outline the association between race/ethnicity and poverty status and perceived anxiety and depressive symptomologies among BRCA1/2-positive United States (US) women to identify high-risk groups of mutation carriers from medically underserved backgrounds.
A total of 211 BRCA1/2-positive women from medically underserved backgrounds were recruited through national Facebook support groups and completed an online survey. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression for associations between race/ethnicity, poverty status, and self-reported moderate-to-severe anxiety and depressive symptoms.
Women ranged in age (18-75, M = 39.5, SD = 10.6). Most women were non-Hispanic white (NHW) (67.2%) and were not impoverished (76.7%). Hispanic women with BRCA1/2 mutations were 6.11 times more likely to report moderate-to-severe anxiety (95% CI, 2.16-17.2, p = 0.001) and 4.28 times more likely to report moderate-to-severe depressive symptoms (95% CI, 1.98-9.60, p < 0.001) than NHW women with these mutations. Associations were not statistically significant among other minority women. Women living in poverty were significantly less likely to report moderate-to-severe depressive symptoms than women not in poverty (aOR, 0.42, 95% CI, 0.18-0.95, p = 0.04).
Hispanic women with BRCA1/2 mutations from medically underserved backgrounds are an important population at increased risk for worse anxiety and depressive symptomology. Our findings among Hispanic women with BRCA1/2 mutations add to the growing body of literature focused on ethnic disparities experienced across the cancer control continuum.
概述美国（US）BRCA1/2 阳性女性中种族/民族和贫困状况与焦虑和抑郁症状之间的关联，以确定来自医疗服务不足背景的突变携带者的高危人群。
通过全国 Facebook 支持小组招募了 211 名来自医疗服务不足背景的 BRCA1/2 阳性女性，并完成了在线调查。使用多变量逻辑回归估计调整后的优势比（aOR）和 95%置信区间（CI），以评估种族/民族、贫困状况与自我报告的中重度焦虑和抑郁症状之间的关联。
女性年龄在 18-75 岁之间（M=39.5，SD=10.6）。大多数女性是非西班牙裔白人（NHW）（67.2%）且不穷困（76.7%）。携带 BRCA1/2 突变的西班牙裔女性报告中重度焦虑的可能性是携带这些突变的 NHW 女性的 6.11 倍（95%CI，2.16-17.2，p=0.001），报告中重度抑郁症状的可能性是携带这些突变的 NHW 女性的 4.28 倍（95%CI，1.98-9.60，p<0.001）。其他少数族裔女性之间的关联没有统计学意义。生活贫困的女性报告中重度抑郁症状的可能性明显低于不贫困的女性（aOR，0.42，95%CI，0.18-0.95，p=0.04）。
来自医疗服务不足背景的携带 BRCA1/2 突变的西班牙裔女性是焦虑和抑郁症状恶化风险较高的重要人群。我们在携带 BRCA1/2 突变的西班牙裔女性中的发现增加了越来越多的关注癌症控制连续体中经历的种族差异的文献。
