Department of Endocrinology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 310003 Hangzhou, Zhejiang, China.
Front Biosci (Landmark Ed). 2022 Mar 18;27(3):107. doi: 10.31083/j.fbl2703107.
Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China. Obesity is closely related to unbalanced cellular energy metabolism. Mitochondria, as the main organelles of energy metabolism, play an important role in the pathophysiology of obesity. Recent researches have revealed that mitochondrial dynamics with constant fission and fusion, can alter mitochondrial structure, organelle connections, ROS production, neuronal activity, and OXPHOS system as well as adipose tissue thermogenesis, which ultimately lead to obesity. In this review, we will update the latest findings about mitochondrial fission/fusion related GTPase proteins and discuss the effects of mitochondrial dynamics in the pathophysiology of obesity.
肥胖已成为一个紧迫且严重的公共卫生挑战，在过去几十年中，肥胖在全球范围内呈压倒性增长。肥胖儿童和青少年的比例最近加速上升，尤其是在中国。肥胖与细胞能量代谢失衡密切相关。线粒体作为能量代谢的主要细胞器，在肥胖的病理生理学中起着重要作用。最近的研究揭示了线粒体的动态分裂和融合，可改变线粒体结构、细胞器连接、ROS 产生、神经元活性和 OXPHOS 系统以及脂肪组织的产热，最终导致肥胖。在这篇综述中，我们将更新与线粒体分裂/融合相关 GTPase 蛋白的最新发现，并讨论线粒体动力学在肥胖病理生理学中的作用。
