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一例放射性药物针刺伤的病例报告,包括闪烁显像和剂量定量分析

A case report of radiopharmaceutical needlestick injury with scintigraphic imaging and dose quantification.

作者信息

Elliott James, Weatherley Mariq

机构信息

School of Allied and Public Health Professions, Canterbury Christ Church University, North Holmes Road Campus, Canterbury Kent, CT1 1QU, UK.

Maidstone Nuclear Medicine Department, Maidstone and Tunbridge Wells NHS Trust, Kent, UK.

出版信息

Radiol Case Rep. 2022 Mar 24;17(5):1718-1721. doi: 10.1016/j.radcr.2022.02.055. eCollection 2022 May.

Abstract

Attention to the implications of common needle stick injuries has focused heavily on the risk of cross-infection from blood-borne pathogens. An additional risk to the nuclear medicine healthcare worker is that of subcutaneous radioactive contamination from radiopharmaceuticals. This case report provides a rare opportunity to examine the clinical and operator causes of one such event during the dispensing of Tc-Tetrofosmin. Contamination monitoring, scintigraphic imaging, and quantification of effective radiation dose provide the level of risk to the operator from the subcutaneous radioactive contamination. Findings demonstrated a very low dose to operator and no deterministic radiobiological effects. Delayed imaging demonstrated negligible biological clearance from the injury site. Implications of the findings for clinical practice are discussed, highlighting the need for a careful and calm approach to radiopharmacy activities.

摘要

对常见针刺伤影响的关注主要集中在血源性病原体交叉感染的风险上。核医学医护人员面临的另一个风险是来自放射性药物的皮下放射性污染。本病例报告提供了一个难得的机会,来审视在锝-替曲膦给药过程中发生的此类事件的临床及操作原因。污染监测、闪烁成像以及有效辐射剂量的量化,确定了皮下放射性污染对操作人员的风险水平。结果表明操作人员所受剂量极低,且未出现确定性放射生物学效应。延迟成像显示损伤部位的生物清除可忽略不计。文中讨论了这些结果对临床实践的意义,强调了在放射性药物操作活动中采取谨慎、冷静态度的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f5/8956908/b4fc261de161/gr1.jpg

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