Hannedouche T, Fillastre J P
Nephrologie. 1986;7(3):94-103.
Anti-hypertensive drugs which are mainly eliminated by the kidney can accumulate in renal failure. Posology of hydrosoluble beta-blockers, converting enzyme inhibitors and central anti-hypertensive drugs should therefore be reduced. Anti-hypertensive drugs whose metabolism is predominantly or exclusively hepatic, such as liposoluble beta-blockers, calcium antagonists and prazosin, can be used at usual posologies. At end-stage renal failure posology of diuretics may have to be increased in order to attain a pharmacodynamic effect.
主要经肾脏消除的抗高血压药物可在肾衰竭时蓄积。因此，水溶性β受体阻滞剂、转换酶抑制剂和中枢性抗高血压药物的剂量应减少。代谢主要或完全经肝脏的抗高血压药物，如脂溶性β受体阻滞剂、钙拮抗剂和哌唑嗪，可按常用剂量使用。在终末期肾衰竭时，可能必须增加利尿剂的剂量以达到药效学效果。
