Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, PR China.
Nutr Metab Cardiovasc Dis. 2022 Jun;32(6):1427-1436. doi: 10.1016/j.numecd.2022.03.006. Epub 2022 Mar 15.
Evidence on the association of snoring, daily sleep duration (daytime napping and night sleep duration) with hyperuricemia (HUA) was limited, especially in the resources-poor areas. This study aimed to investigate the independent effect of snoring frequency and daily sleep duration on HUA prevalence in rural Chinese adults.
29,643 participants aged 18-79 years were included in the final cross-sectional analysis from the Henan Rural Cohort Study. Multivariate logistic regression and linear regression models with HUA and serum uric acid (SUA) levels as dependent variables were conducted, respectively. Of the 29,643 included adults, 3498 suffered from HUA. Compared to never snoring, the adjusted odds ratio (OR) and 95% confidence interval (CI) of HUA for rare snoring, occasional snoring, and habitual snoring were 1.35 (1.17, 1.56), 1.30 (1.14, 1.47), and 1.59 (1.47, 1.73), respectively (P for trend <0.001). Compared with no napping, participants who had daytime napping of 61-90 and > 91 min were associated with a 29% and 30% increase in the prevalence of HUA, respectively (P for trend <0.001). But in night sleep duration groups, no significant associations were observed. The positive associations between snoring and HUA were attenuated in people aged ≥65 and people with type 2 diabetes mellitus (both P for interaction <0.05).
Habitual snoring or longer daytime napping was independently associated with increased HUA prevalence and SUA levels in rural Chinese adults, which indicates the significance of early intervention and treatment of snoring and longer daytime napping to prevent hyperuricemia.
关于打鼾、每日睡眠时间（白天小睡和夜间睡眠时间）与高尿酸血症（HUA）之间关联的证据有限，尤其是在资源匮乏的地区。本研究旨在调查打鼾频率和每日睡眠时间对中国农村成年人 HUA 患病率的独立影响。
本研究最终对来自河南农村队列研究的 29643 名 18-79 岁的参与者进行了横断面分析。分别以 HUA 和血清尿酸（SUA）水平为因变量，采用多变量逻辑回归和线性回归模型进行分析。在纳入的 29643 名成年人中，有 3498 人患有 HUA。与从不打鼾相比，罕见打鼾、偶尔打鼾和习惯性打鼾的 HUA 调整后的比值比（OR）和 95%置信区间（CI）分别为 1.35（1.17，1.56）、1.30（1.14，1.47）和 1.59（1.47，1.73）（P<0.001）。与无小睡相比，白天小睡 61-90 分钟和>91 分钟的参与者发生 HUA 的概率分别增加了 29%和 30%（P<0.001）。但在夜间睡眠时间组中，未观察到显著相关性。在年龄≥65 岁和 2 型糖尿病患者中，打鼾与 HUA 之间的正相关减弱（两者的交互作用 P 值均<0.05）。
习惯性打鼾或白天小睡时间延长与中国农村成年人 HUA 患病率和 SUA 水平升高独立相关，这表明早期干预和治疗打鼾和白天小睡时间延长对于预防高尿酸血症具有重要意义。
